目的 研究成人急性脑损伤患者格拉斯哥昏迷评分（GCS）与脑电双频指数（BIS）值的相关性，探讨BIS值评估脑损伤程度的可行性。方法 采用前瞻、双盲法，收集89例成人急性脑损伤患者GCS和BIS值，计算不同程度脑损伤患者的BIS平均值，对BIS与GCS值行一元线性回归，分别绘制诊断GCS<9和诊断GCS<13的受试者工作（ROC）曲线。结果 轻、中、重度脑损伤组患者的BIS值分别为81.29±7.29、69.32±8.50、45.79±12.39，组间比较差异均有统计学意义（P<0.01）。BIS值与GCS值呈线性正相关（R²=0.825，P<0.01），回归方程BIS=4.23×GCS+22.22。诊断GCS<9的ROC曲线：曲线下面积（AUC）=0.963，截断点BIS=63.8时，敏感度+特异度最大（敏感度=0.932，特异度=0.933）；诊断GCS<13的ROC曲线：AUC=0.933，截断点BIS=71.6时，敏感度+特异度最大（敏感度=0.905，特异度=0.851）。结论 急性脑损伤患者的BIS值与GCS值呈显著正相关，作为一种连续、实时、客观的方法，BIS可成为新型的脑损伤程度评估和监测工具。

Objective To investigate the correlation between Glasgow coma scale (GCS) and bispectral index (BIS) in adults with acute brain injury, and explore the feasibility of BIS value in assessment of brain injury. Methods The prospective and double-blinded design was adopted, and the GCS and BIS values of 89 adults were collected. The mean BIS values of patients with different severity of brain injury were calculated. Linear regression between BIS value and GCS value was constructed, and receiver operating characteristic (ROC) curves at GCS <9 or <13 were plotted respectively. Results There were significant differences in BIS values among patients with mild, moderate and severe brain injury (81.29±7.29, 69.32±8.50 and 45.79±12.39 respectively, P<0.01). There was a significantly

positive correlation between GCS value and BIS value (R²=0.825, P<0.01). The regression equation was BIS=4.23×GCS+22.22. The ROC curve at GCS<9

demonstrated that the area under the curve (AUC) was 0.963, and the cut-off point (BIS value) corresponding with the maximum sensitivity (0.932) and

specificity (0.933) was 63.8.The ROC curve at GCS score<13 demonstrated that AUC was 0.933, and the cut-off point (BIS value) corresponding with the

maximum sensitivity (0.905) and specificity (0.851) was 71.6. Conclusion BIS value significantly correlates with GCS value in adults with acute brain

injury. As a continuous, real-time and objective parameter, BIS can be used as a new tool to assess and monitor the severity of brain injury.