目的 观察角膜缘干细胞移植联合羊膜覆盖治疗巨大翼状胬肉并眼表重建的疗效。方法 回顾性分析2012年1—6月收治的13例（14眼）巨大翼状胬肉病例。均采用翼状胬肉切除加角膜缘干细胞移植、羊膜覆盖术。术中使用0.02%的丝裂霉素C作用于巩膜床1 min。结果 术后随访1年，无复发病例，角膜透明或遗留角膜云翳，无角膜溶解、角膜内皮失代偿等严重并发症。结论 角膜缘干细胞移植联合羊膜覆盖可以有效的降低翼状胬肉的复发率，减轻术后刺激症状，促进创面愈合，有利于眼表结构的重建。

Objective To observe the outcome of combined limbal conjunctival autograft and amniotic membrane covering in the treatment of huge pterygium and ocular surface reconstruction. Methods The clinical data of 13 patients (14 eyes) with huge pterygium treated between January 2012 and June 2012 were retrospectively analysed. All patients were managed with pterygium excision, limbal conjunctival autograft combined with amniotic membrane covering. During operation, 0.02% mitomycin C was applied to the scleral bed for 1 min. Results Patients were followed up for one year, and no recurrence occurred. The corneas were transparent or clouding, and no corneal melting, corneal endothelial decompensation or other serious complications were found. Conclusion Limbal conjunctival autograft combined with amniotic membrane covering can effectively reduce the recurrence rate of pterygium, decrease postoperative irritation, and promote wound healing, which is conducive to the reconstruction of ocular structures.