血小板整合素αⅡbβ3与配体间的相互作用在血栓形成过程中起重要作用，各种激动剂与血小板上相应的受体结合后，启动整合素αⅡbβ3内向外信号转导通路，导致整合素αⅡbβ3活化，与其配体结合进一步启动外向内信号转导。双向信号转导过程中涉及多种蛋白，talin、kindlin和Src是目前研究较多的蛋白，其中talin和kindlin是整合素αⅡbβ3内向外信号转导过程中的重要蛋白，Src则是外向内信号转导的重要蛋白。文章就talin、kindlin和Src研究进展进行综述。

Integrin αⅡbβ3 plays a pivotal role in platelet activation by interacting with ligands and mediating the signal transduction. After various agonists bind to their acceptors on platelets, the inside-out signaling develops, then the outside-in signaling happens. Talin, kindlin and Src, which are important signaling proteins involved in these progresses, have been intensively studied. Talin and kindlin are essential in inside-out signaling, while Src is important in outside-in signaling. This review focuses on the research progress of talin, kindlin and Src.