网络出版日期: 2013-10-31
Research progress of genes in lung cancer target therapy and clinical molecular pathological detection
Online published: 2013-10-31
张 杰 . 肺癌治疗靶向基因研究进展及临床分子病理检测[J]. 上海交通大学学报(医学版), 2013 , 33(10) : 1315 . DOI: 10.3969/j.issn.1674-8115.2013.10.001
Considerable progress has been made in lung cancer therapy targeted on epidermal growth factor receptor (EGFR) mutation and anaplastic lymphoma kinase (ALK) infusion. The mechanism of genes in lung cancer target therapy, such as EGFR, K-RAS, BRAF, C-MET, EML4-ALK, ROS1 and their relationship with EGFR tyrosine kinase inhibitor (EGFR-TKI) and ALK gene infusion inhibitor are introduced. Meanwhile, important requirements in gene detection are elaborated, including the requirements for specimens, choice of methods and quality control in gene detection of lung cancer.
/
〈 |
|
〉 |