乳腺癌转移抑制因子1 （BRMS1）能抑制肿瘤转移并与肿瘤预后密切相关。BRMS1的卷曲螺旋结构能与分选连接蛋白6 （SNX6）富含AT的结构域一起形成六聚体，而核定位信号2 （NLS2）帮助BRMS1发挥转移抑制作用。BRMS1作为mSin3:组蛋白去乙酰化酶复合体（mSin3:HDAC）中的一员，能抑制核转录因子-κB （NF-κB）及其下游的尿激酶型纤溶酶原激活剂（uPA）、骨桥蛋白（OPN）和表皮生长因子受体（EGFR）等信号通路，恢复同型间细胞连接蛋白的表达，促进或抑制肿瘤转移相关的miRNA表达，从而对卵巢癌、黑色素瘤、非小细胞肺癌等多种肿瘤的转移起到抑制作用。该文对有关BRMS1介导的抑制肿瘤转移及其主要机制作一综述。

Breast cancer metastasis suppressor 1 (BRMS1) serves as a tumor suppressor correlated with tumor metastasis and prognosis. The coiled-coil motifs of BRMS1 have the capability of homo-oligomerizing to form a trio of dimers and mediates physical association with the Sorting Nexin 6 (SNX6), and nuclear localization signal 2 （NLS2）is discovered critical to the suppressor function. BRMS1, by forming complexes with mSin-histone deacetylase complex (mSin:HDAC), suppresses expression or activities of multiple downstream targets including nuclear factor-kappa B (NF-κB), urokinase-type plasminogen activator (uPA), osteopontin (OPN), and epidermal growth factor receptor (EGFR) as well as metastasis-promoting miRNA, which affect metastasis of ovarian cancer, melanoma, and non-small cell lung cancer. In this article, recent advances on BRMS1 suppression metastasis are reviewed.