目的 探讨长期使用喹硫平治疗对阿尔茨海默病（AD）患者认知功能的影响。方法 纳入51例伴有精神行为症状的门诊AD患者，随机分为治疗组（服用喹硫平，n=26）和对照组（未服用喹硫平，n=25）。分别于治疗前（基线）、治疗3个月和6个月时采用认知能力筛查量表（CASI）和老年性痴呆评定量表认知分量表（ADAS-cog）评估两组患者的认知功能。结果 两组AD患者的CASI和ADAS-cog基线评分比较差异无统计学意义（P>0.05）；3个月后，两组的CASI和ADAS-cog评分均有所提高，但差异无统计学意义（P>0.05）；6个月后，两组的CASI及ADAScog评分进一步提高，其中治疗组的ADAS-cog评分显著高于对照组，差异有统计学意义（P<0.05）。结论 长期使用喹硫平治疗可能对AD患者的认知功能产生不利影响。

Objective To investigate the effect of long-term administration of quetiapine on the cognitive function of patients with Alzheimer′s disease (AD). MethodsFifty-one AD outpatients with psychological and behavioral symptoms were randomly divided into treatment group (taking quetiapine, n=26) and control group (n=25). Cognitive Abilities Screening Instrument (CASI) and Alzheimer′s Disease Assessment Scale (ADAS-cog) were used to assess the cognitive function of two groups before treatment (baseline), and three months, six months after treatment. Results The baseline scores of CASI and ADAS-cog of two groups were not statistically significant (P>0.05). Three months after treatment, the scores of CASI and ADAS-cog increased but were not statistically significant (P>0.05). Six months after treatment, the scores of CASI and ADAS-cog further increased. The scores of treatment group were obviously higher than those of the control group and statistically significant (P<0.05). Conclusion Long-term administration of quetiapine may cause an adverse impact on the cognitive function of AD patients.