糖尿病视网膜病变中内质网应激和HIF-1对VEGF的调控机制研究进展
网络出版日期: 2014-03-25
基金资助
上海市自然科学基金(10ZR1418500)
Advances of regulation of endoplasmic reticulum stress and HIF-1 to VEGF in diabetic retinopathy
Online published: 2014-03-25
Supported by
Natural Science Foundation of Shanghai,10ZR1418500
王 静 , 朱 鸿 , 施彩虹 . 糖尿病视网膜病变中内质网应激和HIF-1对VEGF的调控机制研究进展[J]. 上海交通大学学报(医学版), 2014 , 34(2) : 240 . DOI: 10.3969/j.issn.1674-8115.2014.02.025
Diabetic retinopathy is one of the most severe microvascular complications of diabetes mellitus, which can lead to irreversible blindness. The main pathological changes of DR are breakdown of blood-retinal barrier and neovascularization. Vascular endothelial growth factor (VEGF) is considered to be the most important intraocular neovascularization factor. Recent researches show that endoplasmic reticulum stress (ERS) and hypoxia-inducible factor-1 (HIF-1) can regulate the expression of VEGF and advance the progress of diabetic retinopathy together. This paper reviews the latest advance of the regulation mechanism of ERS and HIF-1 to VEGF.
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