综述

糖尿病视网膜病变中内质网应激和HIF-1对VEGF的调控机制研究进展

  • 王 静 ,
  • 朱 鸿 ,
  • 施彩虹
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  • 1.上海交通大学 医学院附属第三人民医院眼科, 上海 201900; 2.上海交通大学附属第一人民医院眼科, 上海 200080
王静(1989—), 女, 硕士生; 电子信箱: wangjing2034@126.com; 朱 鸿(1979—), 女, 博士生; 电子信箱: zhuhongchina@126.com。 *为共同第一作者。

网络出版日期: 2014-03-25

基金资助

上海市自然科学基金(10ZR1418500)

Advances of regulation of endoplasmic reticulum stress and HIF-1 to VEGF in diabetic retinopathy

  • WANG Jing ,
  • ZHU Hong ,
  • SHI Cai-hong
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  • 1.Department of Ophthalmology, the Third People′s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 201900, China; 2.Department of Ophthalmology, the First People′s Hospital, Shanghai Jiao Tong University, Shanghai 200080,  China

Online published: 2014-03-25

Supported by

Natural Science Foundation of Shanghai,10ZR1418500

摘要

糖尿病视网膜病变(DR)是糖尿病严重的微血管并发症之一,可导致不可逆的失明,DR的基本病理改变是血-视网膜屏障破坏和新生血管形成,而血管内皮生长因子(VEGF)是公认的最重要的眼内新生血管生长因子。近来研究发现,内质网应激(ERS)和低氧诱导因子-1 (HIF-1)能够调控VEGF的表达,共同促进DR的病程发展。该文就ERS和HIF-1对于VEGF的调控机制方面的研究进展进行综述。

本文引用格式

王 静 , 朱 鸿 , 施彩虹 . 糖尿病视网膜病变中内质网应激和HIF-1对VEGF的调控机制研究进展[J]. 上海交通大学学报(医学版), 2014 , 34(2) : 240 . DOI: 10.3969/j.issn.1674-8115.2014.02.025

Abstract

Diabetic retinopathy is one of the most severe microvascular complications of diabetes mellitus, which can lead to irreversible blindness. The main pathological changes of DR are breakdown of blood-retinal barrier and neovascularization. Vascular endothelial growth factor (VEGF) is considered to be the most important intraocular neovascularization factor. Recent researches show that endoplasmic reticulum stress (ERS) and hypoxia-inducible factor-1 (HIF-1) can regulate the expression of VEGF and advance the progress of diabetic retinopathy together. This paper reviews the latest advance of the regulation mechanism of ERS and HIF-1 to VEGF.

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