目的 探讨雌激素受体α （ERα)不同异构体在子宫内膜癌（EC）中的生物学作用及对EC患者预后的影响。方法 对116例雌激素依赖型EC患者进行回顾性研究，分析EC组织中ERα表达谱与肿瘤临床病理指标、预后的相关性。采用Real-Time PCR检测患者肿瘤组织石蜡切片中RNA的目标基因表达量。结果 ERα表达与EC的分化程度(rs=-0.214, Spearman's test)、淋巴转移(rs=-0.186, Spearman's test)及国际妇产科联盟（FIGO）分期(rs=-0.221, Spearman's test)相关。ERα7号外显子缺失表型（Δ7）是表达量最多的一种异构体，其表达量与肿瘤的分化及FIGO分期相关，且Δ7表达量高者较表达量低者预后佳（疾病特异性生存率P=0.026，疾病无进展生存率P=0.038）。结论 ERαΔ7异构体的表达是决定EC预后的独立危险因子，影响肿瘤患者预后。

Objective To explore the impacts of different estrogen receptor α (ERα) isoforms on biological effects of endometrial cancer (EC) and the prognosis of EC patients. Methods A retrospective study was carried out for 116 endometrial cancer patients and an analysis of relationship between the ERα isoform expression pattern of EC tissue and the clinicopathological data and prognosis was performed. Patients' RNAs were extracted from paraffin sections and Real-Time PCR was used to analyze the gene's expression level. Results ERα expression level was related to the tumor differentiation grade (rs=-0.214, Spearman's test), lymphonode metastases (rs=-0.186, Spearman's test), and FIGO stage (rs=-0.221, Spearman's test). ERα exon 7 skipping isoform (Δ7) was the most commonly detected isoform.  Δ7 was related to the tumor differentiation and FIGO stage and its high expression level was found relating to the preferred surviva (diseasespecific survival P=0.026, disease-progression free survival P=0.038). Conclusion ERαΔ7 is an independent prognosis factor of endometrial cancer and its expression level affects the prognosis of endometrial cancer patients.