上海交通大学学报（医学版）

上海交通大学学报（医学版） >

2014 , Vol. 34 >Issue 8: 1167

DOI: https://doi.org/10.3969/j.issn.1674-8115.2014.08.012

论著（临床研究）

多体素磁共振波谱在低级别胶质瘤鉴别诊断中的应用

  • 赵 倩 ,
  • 史长征 ,
  • 罗良平 ,
  • 等
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  • 1.广州医科大学公共卫生学院统计系，广州 510182；2.暨南大学附属第一医院医学影像中心，广州 510630
赵 倩（1981—）, 女, 讲师， 博士; 电子信箱: zhaoqian121@126.com。

网络出版日期: 2014-09-02

基金资助

国家自然科学基金(81202284）；广东省自然科学基金(S2011040004735)；广东高校优秀青年创新人才培养计划项目(LYM11106)

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Application of multi-voxel magnetic resonance spectroscopy in differential diagnosis for low grade gliomas

  • ZHAO Qian ,
  • SHI Chang-zheng ,
  • LUO Liang-ping ,
  • et al
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  • 1.Department of Statistics, School of Public Health, Guangzhou Medical University, Guangzhou 510182, China; 2.Medical Imaging Center, the First Affiliated Hospital, Jinan University, Guangzhou 510630, China

Online published: 2014-09-02

Supported by

National Natural Science Foundation, 81202284; Guangdong Provincial Natural Science Foundation，S2011040004735; Project for Outstanding Young Innovative Talents in Colleges and Universities of Guangdong Province，LYM11106

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摘要

目的 分析多体素磁共振波谱(MRS)对鉴别低级别胶质瘤的意义。方法 回顾性分析30例Ⅱ级胶质瘤患者的MRS，其中星形细胞瘤16例，少突胶质细胞瘤14例。比较不同亚型低级别胶质瘤代谢物浓度及其比值的差异；进行多因素Logistic回归，分析其相关影响因素。结果 星形细胞瘤中Cho、Cr的相对浓度以及Cho/Cr、Cho/NAA比值均高于少突胶质细胞瘤（P<0.05）；多因素Logistic回归分析显示Cho为鉴别低级别星型细胞瘤和少突胶质细胞瘤的相关影响因素(OR=1.153，95%CI: 1.083~1.227，P<0.05)。结论 Cho的相对浓度是鉴别Ⅱ级星形细胞瘤和少突胶质细胞瘤的重要指标。

关键词： 磁共振成像; 脑胶质瘤; 磁共振波谱

本文引用格式

赵 倩 , 史长征 , 罗良平 , 等 . 多体素磁共振波谱在低级别胶质瘤鉴别诊断中的应用[J]. 上海交通大学学报（医学版）, 2014 , 34(8) : 1167 . DOI: 10.3969/j.issn.1674-8115.2014.08.012

Abstract

Objective To evaluate the performance of multi-voxel magnetic resonance spectroscopy (MRS) in differentiating low grade gliomas. Methods Retrospective study was done on 30 cases of grade Ⅱ gliomas (16 cases of astrocytoma and 14 cases of oligodendroglioma) who received MRS. Concentrations of metabolites and relative ratios were compared between the subtype astrocytoma and oligodendroglioma. Stepwise Logistic regression was applied to find the related factors. Results The relative concentrations of Cho and Cr from astrocytoma were higher than those of oligodendroglioma. The relative ratios Cho/Cr and Cho/NAA were also higher than those of oligodendroglioma （P<0.05）. Cho was the related factors in differentiating low grade astrocytoma and oligodendroglioma by Logistic regression model (OR=1.153，95%CI: 1.083-1.227，P<0.05). Conclusion The relative concentrations of Cho could be the important indexes to differentiate astrocytoma and oligodendroglioma in clinic.

Key words： magnetic resonance imaging; rain gliomas; agnetic resonance spectroscopy

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