目的 通过检测白介素-17（IL-17）在不同类型牙周炎患者牙龈组织中的分布以及表达水平，初步探讨IL-17在牙周炎发生和发展中的可能作用。方法 牙龈组织标本分为对照组（n=10）、慢性牙周炎组（n=10）和侵袭性牙周炎组（n=10）。采用免疫组织化学方法检测各组牙龈组织中IL-17的分布和表达水平。结果 IL-17在牙龈上皮和结缔组织全层中均有表达。慢性牙周炎组和侵袭性牙周炎组牙龈组织中IL-17表达水平均显著高于对照组（P<0.01）。侵袭性牙周炎组牙龈上皮和牙龈结缔组织中IL-17表达水平均显著高于慢性牙周炎组（P<0.01）。结论 IL-17参与牙周炎炎症反应的发生和发展，其在不同类型牙周炎患者牙龈组织中的表达存在差异。

Objective To detect the distribution and expression of IL-17 in the gingival tissue of patients with different types of periodontitis and to preliminary explore the possible effects of IL-17 on the occurrence and development of periodontitis. Methods Gingival biopsies were divided into the control group (n=10), chronic periodontitis group (n=10), and aggressive periodontitis group(n=10). The distribution and expression of IL-17 in the gingival tissue of each group were detected by the immunohistochemistry. Results IL-17 expressed in the gingival epithelium and connective tissue full layer. The expressions of IL-17 in the gingival tissue of the chronic periodontitis group and aggressive periodontitis group were significantly higher than that of the control group (P<0.01). The expressions of IL-17 in the gingival epithelium and connective tissue of the aggressive periodontitis group were significantly higher than those of the chronic periodontitis group (P<0.01). Conclusion IL-17 involves in the occurrence and development of periodontal inflammation. The expressions of IL-17 in the gingival tissue of patients with different types of periodontitis are different.