上海交通大学学报（医学版）

上海交通大学学报（医学版） >

2014 , Vol. 34 >Issue 10: 1543

DOI: https://doi.org/10.3969/j.issn.1674-8115.2014.10.026

综述

胎盘生长因子在心肌梗死后的心肌再生治疗中的研究进展

  • 张文天 ,
  • 连 锋 ,
  • 薛 松
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  • 上海交通大学 医学院附属仁济医院心血管外科， 上海 200127
张文天（1988—）， 男， 硕士生; 电子信箱: zwtstzjz@163.com。

网络出版日期: 2014-10-28

基金资助

上海市科委基金（12NM0502100）；上海市教委基金（11YZ48,13ZZ091）

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Research progresses of effects of placental growth factor on myocardial regeneration treatment after acute myocardial infarction

  • ZHANG Wen-tian ,
  • LIAN Feng ,
  • XUE Song
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  • Department of Cardiovascular Surgery, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China

Online published: 2014-10-28

Supported by

Foundation of Science and Technology Commission of Shanghai Municipality, 12NM0502100; Foundation of Shanghai Municipal Education Committee, 11YZ48,13ZZ091

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摘要

急性心肌梗死后，心肌细胞缺氧会刺激心肌细胞和间质细胞释放生长因子促进血管再生和调控心脏重构。胎盘生长因子（PlGF）是心肌组织损伤后的应激产物，它不仅能促进血管再生、调控炎症反应，还与心室重构和干细胞的旁分泌机制有着密切的联系。该文就PlGF在心肌梗死后的心肌再生治疗作一综述。

关键词： 胎盘生长因子; 急性心肌梗死; 血管再生; 心室重构; 旁分泌

本文引用格式

张文天 , 连 锋 , 薛 松 . 胎盘生长因子在心肌梗死后的心肌再生治疗中的研究进展[J]. 上海交通大学学报（医学版）, 2014 , 34(10) : 1543 . DOI: 10.3969/j.issn.1674-8115.2014.10.026

Abstract

Hypoxic condition of myocardial cells will stimulate myocardial cells and interstitial cells to release growth factors to induce angiogenesis and cardiac remodeling after acute myocardial infarction (AMI). Placental growth factor (PlGF) is a stress product after the injury of myocardial tissue. It can not only promote angiogenesis and regulate the inflammatory response, but also closely related to ventricular remodeling and paracrine mechanism of stem cells. This paper reviews the effects of PlGF on the myocardial regeneration treatment after AMI.

Key words： placenta growth factor; acute myocardial infarction; angiogenesis; cardiac remodeling; paracrine

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