抑郁症和颞下颌关节紊乱病(TMD)分别是常见的精神疾病和颞下颌关节疾病之一，对于两者间相关性仍在探究之中。下丘脑—垂体—肾上腺轴、血清素能系统、肿瘤坏死因子-α（TNF-α）和儿茶酚-O-甲基转移酶（COMT）基因等都是抑郁症与颞下颌关节紊乱病可能的内在机制联系因素。治疗抑郁症能够在一定程度上缓解颞下颌关节紊乱病的症状，临床医师应注意抑郁症与颞下颌关节紊乱病并存的可能，并施以适当的治疗。未来的机制研究应着重于抑郁症与颞下颌关节紊乱病的内在联系。本文对抑郁症与颞下颌关节紊乱病症状、机制及治疗相互关系的研究进展进行综述。

Depression is a common mental disease and temporomandibular disorder (TMD) is a common temporomandibular disease. The correlation of two diseases still needs further study. Hypothalamic-pituitary-adrenal (HPA) axis, serotoninergic system, tumor necrosis factor-α (TNF-α), and catechol-O-methyltransferase (COMT) gene are possible internal correlation factors of depression and TMD. The treatment of depression can relieve the symptoms of TMD to some extent. Clinicians should be aware of the coexistence of depression and TMD and conduct proper treatments. Further study should focus on the internal correlation of depression and TMD. This paper reviews research progresses of the correlation among symptoms, mechanism, and treatment of depression and TMD.