论著(临床研究)

高血压病对急性缺血性卒中患者rt-PA静脉溶栓疗效的影响

  • 蔡若蔚 ,
  • 陈雅芳 ,
  • 黄银辉 ,
展开
  • 1.福建医科大学附属第二医院神经内科, 泉州 362000; 2.晋江市医院神经内科, 晋江 362000
蔡若蔚(1958—), 男, 主任医师, 学士; 电子信箱: 251045413@qq.com。

网络出版日期: 2014-12-02

Effects of hypertension on treatment of patients with acute ischemic stroke by rt-PA intravenous thrombolysis

  • CAI Ruo-wei ,
  • CHEN Ya-fang ,
  • HUANG Yin-hui ,
  • et al
Expand
  • 1.Department of Neurology, the Second Affiliated Hospital of Fujian Medical University, Quanzhou 362000, China; 2.Department of Neurology, Jinjiang City Hospital, Jinjiang 362000, China

Online published: 2014-12-02

摘要

目的 探讨高血压病对急性缺血性卒中患者重组组织型纤溶酶原激活剂(rt-PA)静脉溶栓疗效的影响。方法 收集2009年2月—2013年6月间发病4.5 h内给予rt-PA溶栓的急性缺血性卒中患者作为研究对象。采用改良Rankin量表(mRS)评价神经功能恢复状况,并根据mRS评分分为预后良好组(mRS评分0~1分)和预后不良组(mRS评分2~6分)。比较两组临床资料并进行危险因素分析。结果 预后良好组(n=92)与预后不良组(n=83)在高血压病比例方面的差异无统计学意义(66.30% vs 67.47%, P=0.870)。Logistic多因素回归分析结果显示:高血压病既不是症状性颅内出血的危险因素(OR=0.453, 95%CI:0.087~2.352,P=0.346),也不是影响溶栓预后的因素(OR=1.014;95%CI:0.933~1.101,P=0.746)。结论 高血压病对急性缺血性卒中患者静脉溶栓疗效无明显影响。

本文引用格式

蔡若蔚 , 陈雅芳 , 黄银辉 , . 高血压病对急性缺血性卒中患者rt-PA静脉溶栓疗效的影响[J]. 上海交通大学学报(医学版), 2014 , 34(11) : 1622 . DOI: 11.3969/j.issn.1674-8115.2014.11.013

Abstract

Objective To explore the effects of hypertension on the treatment of patients with acute ischemic stroke by recombinant tissue plasminogen activator (rt-PA) intravenous thrombolysis.MethodsPatients with acute ischemic stroke who were administrated intravenous rt-PA within 4.5 h after the onset were selected. The onset time was between February 2009 and June 2013. Modified Rankin Scale (mRS) was used to evaluate the recovery of neurological functions. Patients were divided into the good prognosis group (mRS scores were 0-1) and poor prognosis group (mRS scores were 2-6) according to the scores of mRS. General informations of patients were collected and compared between two group and risk factors were analyzed. Results The difference of the percentage of patients with hypertension of the good prognosis group (n=92) and poor prognosis group (n=83) was not statistically significant (66.30% vs 67.47%,P=0.870). The results of logistic multivariate regression analysis showed that hypertension was neither a risk factor of symptomatic intracranial hemorrhage (OR=0.453, 95%CI: 0.087-2.352, P=0.346) nor a influencing factor of the prognosis of thrombolysis (OR=1.014, 95%CI: 0.933-1.101, P=0.746). Conclusion The hypertension has no significant effect on the treatment of patients with acute ischemic stroke by rt-PA intravenous thrombolysis.

文章导航

/