糖尿病血管病变作为糖尿病主要并发症之一，是由血管外膜、中膜、内膜共同参与的复杂病理生理过程。糖尿病外周血管病变是糖尿病致死、致残的重要原因，早期诊断、预防、治疗糖尿病外周血管病变，对糖尿病患者的生活质量极为重要；而无创、便捷的检测则有助于早期诊断及筛查。文章就糖尿病外周血管病变的病理生理变化、临床表现及部分早期诊断方法进行综述。

As one of the major complications of diabetes, diabetic vasculopathy is a complex pathophysiological process participated by tunica adventitia, media, and intima. The diabetic peripheral vascular disease is an important reason for the death and disability. Early diagnosis, prevention, and treatment are extremely important for the life quality of patients with diabetes mellitus. Noninvasive and simple diagnostic methods greatly benefit the early screening and diagnosis. The pathophysiology, clinical manifestations, and some early diagnostic methods of diabetic peripheral vascular disease are reviewed in this paper.