网络出版日期: 2014-12-30
基金资助
国家临床重点专科建设项目
Added value of 18F-FDG PET/CT for preoperative evaluation of distant metastasis of pancreatic cancer by abdominal contrast-enhanced CT
Online published: 2014-12-30
Supported by
National Leading Clinical Discipline Construction Project
目的 研究18F-FDG PET/CT对腹部增强CT术前评估胰腺癌远处转移的增益价值。方法 回顾分析51例胰腺癌患者的腹部增强CT和18F-FDG PET/CT资料。通过增强CT、增强CT结合18F-FDG PET/CT评估胰腺癌是否发生远处转移,以病理或随访结果为金标准,分析18F-FDG PET/CT的增益价值。结果 增强CT结合18F-FDG PET/CT诊断胰腺癌远处转移的灵敏度、特异度和准确度分别为94.2%(33/35)、100%(16/16)、96.1%(49/51),与单独增强CT的71.4%(25/35)、100%(16/16)、76.5%(41/51)相比,灵敏度和准确度的差异有统计学意义(χ2=6.43, P=0.011; χ2=6.04, P=0.014)。共有26例患者增强CT未检出远处转移,结合18F-FDG PET/CT后,其中6例接近肝包膜直径6.7~9.8 mm的肝转移和2例肺转移被检出。另25例增强CT检出远处转移的患者,结合18F-FDG PET/CT后,评估结果未发生改变。结论 18F-FDG PET/CT对于腹部增强CT未检出远处转移的胰腺癌患者有增益价值,尤其是肝内有直径<1 cm且接近肝包膜的微小病灶患者。
徐 枫 , 席 云 , 张 敏 , 等 . 18F-FDG PET/CT对腹部增强CT术前评估胰腺癌远处转移的增益价值[J]. 上海交通大学学报(医学版), 2014 , 34(12) : 1762 . DOI: 11.3969/j.issn.1674-8115.2014.12.011
Objective To explore the added value of 18F-FDG PET/CT for preoperative evaluation of the distant metastasis of pancreatic cancer by the abdominal contrast-enhanced CT (CE-CT). Methods Data of abdominal CE-CT and 18F-FDG PET/CT of 51 patients with pancreatic cancer were retrospectively analyzed. The distant metastasis of pancreatic cancer was diagnosed by the CE-CT and CE-CT combined with 18F-FDG PET/CT. Results of pathological diagnosis or follow-up were adopted as the golden standard and the added value of 18F-FDG PET/CT was analyzed. Results The sensitivity, specificity, and accuracy of CE-CT combined with 18F-FDG PET/CT for diagnosing the distant metastasis of pancreatic cancer were 94.2% (33/35), 100% (16/16), and 96.1% (49/51). Compared to 71.4% (25/35), 100% (16/16), and 76.5% (41/51) of CE-CT, the differences of sensitivity and accuracy were statistically significant (χ2=6.43, P=0.011; χ2=6.04, P=0.014). A total of 26 patients were diagnosed of no distant metastasis by CE-CT, but 6 of them were diagnosed of liver metastasis (close to the liver capsule with diameter between 6.7-9.8 mm) and 2 of them were diagnosed of lung metastasis by CE-CT combined with 18F-FDG PET/CT. Another 25 patients were diagnosed of distant metastasis by CE-CT and confirmed by CE-CT combined with 18F-FDG PET/CT. Conclusion 18F-FDG PET/CT provides added value for patients who are diagnosed of pancreatic cancer with no distant metastasis by CE-CT, especially for patients with small liver lesion (diameter<1 cm) close to the liver capsular.
Key words: pancreatic neoplasms; neoplasm metastasis; PET/CT; contrast-enhanced CT; diagnosis
/
〈 |
|
〉 |