哺乳动物的心脏发育涉及胚胎多能性细胞分化为中胚层以及心脏各种类型的细胞，包括心肌细胞、内皮细胞和平滑肌细胞，心脏发育需要精细的调控网络。长链非编码RNA（lncRNA）是人类和小鼠转录组中最重要的RNA之一。随着新一代测序技术的发展，对于lncRNA的研究越来越受到重视。文章主要讨论lncRNA在哺乳动物心脏胚胎分化发育的基因调控过程中发挥的重要作用。

Mammalian cardiogenesis involves the differentiation of pluripotent cells in the embryo towards mesoderm and cardiac cell types, including cardiomyocytes, endothelial cells, and smooth muscle cells. The cardiogenesis requires fine regulation network. Long non-coding RNA (lncRNA) is found to be one of the most important RNAs in mouse and human transcriptomes. With the development of new transcriptome sequencing techniques, researches of lncRNA have drawn more and more attention. This paper reviews crucial effects of lncRNA on the gene regulation of cardiac differentiation and development of mammals.