网络出版日期: 2014-12-30
基金资助
上海交通大学医学院大学生创新训练计划(2013007)
Advances of serine starvation and p53 regulating oxidative stress of tumor cells
Online published: 2014-12-30
Supported by
Undergraduate Innovation Program of Shanghai Jiao Tong University School of Medicine, 2013007
张 硕 , 徐冰聪 , 陈立畅 , 等 . 丝氨酸缺乏及p53调控肿瘤氧化应激的研究进展[J]. 上海交通大学学报(医学版), 2014 , 34(12) : 1839 . DOI: 11.3969/j.issn.1674-8115.2014.12.027
Fast proliferation of tumor cells is characterized by energy metabolism abnormality that the major energy supply is glycolysis. The biosynthesis of tumor cells depends on serine. Serine starvation causes oxidative stress of tumor cells and activates p53 gene, which support the survival of tumor cells. The relationship between serine starvation and p53 gene provides new ideas for the metabolic targeted treatment of tumors. This paper reviews research progresses of regulating oxidative stress of tumor cells by serine starvation and p53.
Key words: serine starvation; p53; oxidative stress
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