综述

丝氨酸缺乏及p53调控肿瘤氧化应激的研究进展

  • 张 硕 ,
  • 徐冰聪 ,
  • 陈立畅 ,
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  • 上海交通大学 基础医学院细胞与分子生物学实验室, 上海 200025
张 硕(1992—), 女, 2011级临床医学八年制学生; 电子信箱: akaseki@126.com。

网络出版日期: 2014-12-30

基金资助

上海交通大学医学院大学生创新训练计划(2013007)

Advances of serine starvation and p53 regulating oxidative stress of tumor cells

  • ZHANG Shuo ,
  • XU Bing-cong ,
  • CHEN Li-chang ,
  • et al
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  • Laboratory for Cell and Molecular Biology, Basic Medicine Faculty of Shanghai Jiao Tong University, Shanghai 200025, China

Online published: 2014-12-30

Supported by

Undergraduate Innovation Program of Shanghai Jiao Tong University School of Medicine, 2013007

摘要

肿瘤细胞的快速增殖表现为以糖酵解为主要供能方式的能量代谢异常,肿瘤细胞的生物合成依赖丝氨酸。丝氨酸缺乏可导致肿瘤细胞氧化应激,激活p53基因促进肿瘤细胞的生存。丝氨酸缺乏与p53基因的关系为代谢靶向治疗肿瘤提供了新思路。本文就丝氨酸缺乏与p53调节肿瘤细胞氧化应激的研究进展作一综述。

本文引用格式

张 硕 , 徐冰聪 , 陈立畅 , . 丝氨酸缺乏及p53调控肿瘤氧化应激的研究进展[J]. 上海交通大学学报(医学版), 2014 , 34(12) : 1839 . DOI: 11.3969/j.issn.1674-8115.2014.12.027

Abstract

Fast proliferation of tumor cells is characterized by energy metabolism abnormality that the major energy supply is glycolysis. The biosynthesis of tumor cells depends on serine. Serine starvation causes oxidative stress of tumor cells and activates p53 gene, which support the survival of tumor cells. The relationship between serine starvation and p53 gene provides new ideas for the metabolic targeted treatment of tumors. This paper reviews research progresses of regulating oxidative stress of tumor cells by serine starvation and p53.

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