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GPRC6A及其糖稳态调节作用研究进展

  • 杜 婧 ,
  • 包玉倩
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  • 上海交通大学附属第六人民医院内分泌代谢科 上海市糖尿病临床医学中心 上海市糖尿病研究所 上海市糖尿病重点实验室, 上海 200233
杜 婧(1982—), 女, 主治医师, 博士生; 电子信箱: du_lilian@aliyun.com。

网络出版日期: 2015-01-29

基金资助

国家自然科学基金(81170788)

Advances of GPRC6A and its regulation function of glucose homeostasis

  • DU Jing ,
  • BAO Yu-qian
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  • Department of Endocrinology and Metabolism, Shanghai Sixth People's Hospital, Shanghai Jiao Tong University, Shanghai Clinical Center for Diabetes, Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai 200233, China

Online published: 2015-01-29

Supported by

National Natural Science Foundation of China, 81170788

摘要

G蛋白耦联受体C家族6组A(GPRC6A)是近年来新发现的一种G蛋白耦联受体,可与多种配体如钙离子、碱性氨基酸、骨钙素、睾酮等结合发挥生理作用,并参与机体的糖稳态调节。GPRC6A缺失可能引起糖代谢失衡。深入研究GPRC6A及其糖稳态调节作用可能为糖尿病提供一个新的药物治疗靶点。

本文引用格式

杜 婧 , 包玉倩 . GPRC6A及其糖稳态调节作用研究进展[J]. 上海交通大学学报(医学版), 2015 , 35(1) : 128 . DOI: 11.3969/j.issn.1674-8115.2015.01.025

Abstract

The G protein coupled receptor family C, group 6, subtype A (GPRC6A) is a newly identified G protein coupled receptor, which involves in a broad range of physiological functions by combining with various ligands, such as calcium, basic amino acid, osteocalcin, and steroid, as well as the regulation of glucose homeostasis. Deletion of GPRC6A may cause disturbance of glucose homeostasis. Further study on GPRC6A and its regulation function of glucose homeostasis may identify a new therapeutic target for diabetes.

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