目的 应用基于平滑削边绝对偏离(SCAD)惩罚方法揭示大肠癌术前淋巴结转移因素。方法 对252例大肠癌患者入院检查各项常规指标进行回顾性分析，应用SCAD惩罚方法筛选出影响淋巴结转移的主要因素，并推算出模型参数。结果 统计结果显示腹痛、血便、癌胚抗原以及血清总胆汁酸4项数据异常对大肠癌淋巴转移的影响有统计学意义，进而可以根据模型推算大肠癌患者的淋巴结转移概率。结论 SCAD统计学研究的结果可在临床上用于手术前评估大肠癌患者淋巴结转移发生的概率，指导手术前的干预治疗。

Objective To reveal the influencing factors of preoperative lymph node metastasis of colorectal cancer by the smoothly clipped absolute deviation (SCAD) penalty technology. Methods Clinical data of 252 patients with colorectal cancer were analyzed retrospectively. By using SCAD technology, the main influencing factors of the lymph node metastasis were sifted and the model parameters were also calculated. Results The statistical results showed that the effects of abnormality in abdominal pain, bloody stools, carcinoembryonic antigen, and serum total bile acid on the lymph node metastasis of colorectal cancer were statistically significant. The probability of lymph node metastasis of patients with colorectal cancer was calculated based on the model. Conclusion The results of SCAD can be clinically applied to preoperative estimation of the possibility of lymph node metastasis for patients with colorectal cancer and guidance of the preoperative intervention therapy.