上海交通大学学报（医学版）

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2015 , Vol. 35 >Issue 4: 585

DOI: https://doi.org/11.3969/j.issn.1674-8115.2015.04.024

综述

羧基酯脂肪酶与糖尿病和胰腺外分泌疾病相关性的研究进展

  • 张荣 ,
  • 刘丽梅
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  • 上海交通大学附属第六人民医院内分泌代谢科 上海市糖尿病研究所， 上海 200233
张荣（1988—）， 女， 硕士生; 电子信箱: zhang_rong0428@126.com。

网络出版日期: 2015-04-29

基金资助

国家自然科学基金(81471012, 81270876, 30771022)；上海市科委优秀学科带头人基金

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Advances of carboxyl ester lipase, diabetes, and pancreatic exocrine diseases

  • ZHANG Rong ,
  • LIU Li-mei
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  • Department of Endocrinology and Metabolism， Shanghai Diabetes Institute， Shanghai Sixth People's Hospital， Shanghai Jiao Tong University， Shanghai 200233， China

Online published: 2015-04-29

Supported by

National Natural Science Foundation of China, 81471012, 81270876, 30771022; Outstanding Academic Leaders Foundation of Science and Technology Commission of Shanghai Municipality, 10XD1403400

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摘要

羧基酯脂肪酶(CEL)基因编码的蛋白是由胰腺腺泡细胞分泌的胆固醇酯的水解酶，是与青少年发病的成人型糖尿病（MODY）相关的7种分子中唯一非胰岛β细胞合成和分泌的蛋白。CEL基因的可变数目串联重复序列(VNTR）突变可以导致MODY-胰外分泌综合征、胰岛素依赖型糖尿病（1型糖尿病）或非胰岛素依赖型糖尿病（2型糖尿病）及酒精性胰腺炎等胰腺外分泌疾病。该文就CEL基因突变/变异与糖尿病和/或胰腺外分泌疾病相关性的研究进展进行综述。

关键词： 羧基酯脂肪酶; 青少年发病的成人型糖尿病; 胰腺外分泌疾病

本文引用格式

张荣 , 刘丽梅 . 羧基酯脂肪酶与糖尿病和胰腺外分泌疾病相关性的研究进展[J]. 上海交通大学学报（医学版）, 2015 , 35(4) : 585 . DOI: 11.3969/j.issn.1674-8115.2015.04.024

Abstract

The protein encoded by carboxyl ester lipase (CEL) gene is a kind of cholesterol ester hydrolase secreted by pancreatic acinar cells and is the only protein that is not synthesized and secreted by islet beta cells in 7 molecules relevant to the maturity-onset diabetes of the young (MODY). Mutations of the variable-number tandem repeat (VNTR) of CEL can cause the syndrome of MODY and pancreatic exocrine dysfunction, insulin-dependent diabetes mellitus (type 1 diabetes) or noninsulin-dependent diabetes mellitus (type 2 diabetes), and pancreatic exocrine diseases such as alcoholic pancreatitis. This paper reviews latest research progresses of gene mutations of CEL, diabetes, and pancreatic exocrine diseases.

Key words： carboxyl ester lipase; maturity-onset diabetes of the young; pancreatic exocrine dysfunction

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