目的  将多通道在体记录技术与癫痫模型的构建相结合，为研究癫痫网络机制提供一种新的实验方法。方法  采用多通道在体记录技术同时记录杏仁核电点燃小鼠点燃过程中背外侧杏仁核、海马CA1、初级体感皮层和丘脑背内侧核的电活动。在记录电信号的同时，观察小鼠的行为学状态。结果  在1～5级癫痫发作时，4个记录区域均可记录到后放电，且后放电的持续时间随着癫痫发作级别的增大而增加。癫痫发生和发展过程中伴随频域特异性的电信号动态变化。结论  该实验方法有望成为探索癫痫发作和形成过程中网络机制的一种有价值的研究方法。

Objective  To provide a new experimental method for studying the mechanisms of epileptic network by integrating the multi-channel in vivo recording techniques and the establishment of epilepsy model. Methods  Multi-channel in vivo recording techniques were adopted to simultaneously record neural activities of the basolateral amygdala, cornu ammonis 1 of hippocampus, primary somatosensory cortex, and mediodorsal thalamus of amygdala-kindling mice. Meanwhile, behaviors of mice were also observed and recorded. Results  The afterdischarge was recorded in four recording regions for epilepsy from grade 1 to 5 and the duration of afterdischarge increased with the grade of epilepsy. The incidence and development of epilepsy accompanied dynamic changes of frequency-specific electrical signals. Conclusion  This experimental method may be a valuable method for study the network mechanism of the ictogenesis and epileptogenesis.