网络出版日期: 2015-12-22
基金资助
国家自然科学基金(91232719);国家临床重点专科-上海市精神卫生中心(卫生部医政司2011-873);科技部“十二五”国家科技支撑项目 (2012BAI01B04)
Ras signaling pathway and neural plasticity mechanism of depression
Online published: 2015-12-22
Supported by
National Natural Science Foundation of China, 91232719; National Key Clinical Disciplines at Shanghai Mental Health Center, OMA-MH 2011-873; National Key Technology Research and Development Program of the Ministry of Science and Technology of China in the “12th Five-Year Plan”, 2012BAI01B04
王凡 , 张晨 , 方贻儒 . Ras信号通路与抑郁症神经可塑性机制[J]. 上海交通大学学报(医学版), 2015 , 35(10) : 1556 . DOI: 10.3969/j.issn.1674-8115.2015.10.025
The pathogenesis of depression has not been clearly elucidated yet. In recent years, more and more evidences highlight the role of neural plasticity mechanism in the pathogenesis and treatment of depression. Particularly, neurotrophic factors are critical for the neural plasticity. Meanwhile the Ras signaling pathway, a vital downstream signaling pathway of the neurotrophic factor receptor, plays an important role in the neural plasticity. This paper reviews studies relevant to Ras signaling pathways and the neural plasticity mechanism of depression.
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