网络出版日期: 2015-12-22
基金资助
上海交通大学医学院脑疾病临床研究中心项目（20150626）；上海市卫生系统先进适宜技术推广项目（2013SY003）；上海市科委医学引导类项目（14411961400）
Advances of γ-aminobutyric acid of patients with schizophrenia by proton magnetic resonance spectroscopy
Online published: 2015-12-22
Supported by
Project of Brain Diseases Clinical Research Center, Shanghai Jiao Tong University School of Medicine， 20150626; Shanghai Health System Advanced Appropriate Technology Promotion Project， 2013SY003; Medical Guide Project of Shanghai Science and Technology Commission， 14411961400
王俊杰 , 唐莺莹 , 王继军 . 质子磁波谱技术对γ-氨基丁酸在精神分裂症中的研究进展[J]. 上海交通大学学报（医学版）, 2015 , 35(10) : 1585 . DOI: 10.3969/j.issn.1674-8115.2015.10.031
Schizophrenia is a common severe mental illness with high rate of relapse and disability, but the pathogenesis is unknown. Gama-aminobutyric acid (GABA) is the major inhibitory neurotransmitter, which is relevant to pathophysiological mechanisms of schizophrenia. Proton magnetic resonance spectroscopy is a non-invasive technique for directly measuring the regional GABA level of patient’s brain in vivo, which provides a novel idea for investigating the pathogenesis of schizophrenia and developing new intervention measures. This paper reviews progresses of studying GABA of patients with schizophrenia by proton magnetic resonance spectroscopy.
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