目的  评价上海交通大学医学院附属仁济医院南院（简称“仁济南院”）降糖药物的用药合理性。方法  采用药物利用评估方法，收集2013年第1季度—2015年第2季度仁济南院非胰岛素依赖型糖尿病患者的用药信息并进行统计学分析。结果  抗糖尿病药物处方量逐年上升，2015年第2季度销售金额是2013年第1季度的近3倍，胰岛素类药物的占比近50%，其中普通胰岛素注射液（国产）无论销售金额还是用药频度（DDDs）均排名第一。DDDs显示常用的口服降糖药是格列齐特缓释片（进口）、二甲双胍（进口）与伏格列波糖（进口）。销售金额排序与DDDs排序比值大于1与小于1的各有6个（24%）与16个（64%）。结论  随着糖尿病患者门诊人数的增加，仁济南院的降糖药物处方量与销售金额显著上升。虽然降糖药物的使用基本合理，但应该更多地选择用药金额与DDDs同步性好的药物。

Objective  To evaluate the rationality of the use of glucose lowering drugs for the Renji Hospital South Campus, Shanghai Jiao Tong University School of Medicine. Methods  The drug use and evaluation method was adopted and drug use information of patients with type 2 diabetes who were admitted by the Renji Hospital South Campus from the first quarter of 2013 to the second quarter of 2015 was collected and statistically analyzed. Results  The prescriptions of glucose lowering drugs increased annually. The sales amount of the second quarter of 2015 was about 3 times higher than that of the first quarter of 2013. Insulin drugs accounted for about 50% and both the sales amount and defined daily dose (DDD) of general insulin injection (domestic) were ranked as No.1 among all drugs. According to DDDs, commonly used oral glucose lowering drugs were gliclazide (imported), metformin (imported), and voglibose (imported). There were 6 drugs (24%) and 16 drugs (64%) with the ratio of ranks of sales amount and DDD larger than 1 and smaller than 1. Conclusion  The prescriptions and sales amount of glucose lowering drugs of Renji Hospital South Campus increase significantly with the number of outpatients with type 2 diabetes. Basically, the use of the glucose lowering drugs is reasonable, but drugs with better synchronization of the cost and the frequency should be used.