雌激素类药物是防治骨质疏松的有效药物。为了提高机体对药物的吸收率和生物利用度，增强药物对骨骼系统的亲和力，减少长期应用出现的不良反应，近年来从药物靶向性和药物合成角度对雌激素类药物作了一些新的改进，其中应用较广泛的有雌激素控释纳米载体，以及小肽、四环素类和RGD多肽的骨靶向性药物，为骨质疏松的治疗提供了新的方法和思路。该文对此研究进展进行综述。

Estrogen-like drugs are efficient for prevention and treatment of osteoporosis. In order to improve absorptivity and bioavailability for estrogen-like drugs in human body, enhance affinity between estrogen-like drugs and skeletal system, and reduce adverse reactions due to long term administration, new improvements in estrogen-like drugs have been made in terms of drug targeting and drug synthesis in recent years. Estrogen controlled release nano-carriers and some small peptide, tetracycline and RGD-peptide bone-targeting drugs are widely used, which provide novel methods and ideas for osteoporosis treatment. In this paper, research progresses of estrogen-like drugs are reviewed.