目的 评价黄麦合剂对阳虚动物模型的保护作用及对雄性大鼠、小鼠生殖功能的影响。方法 建立氢化可的松造成的小鼠阳虚模型、雄性大鼠去势造成的肾阳虚模型，观察黄麦合剂给药后的大鼠血清睾酮含量，生殖系统相关器官及腺体包括前列腺、精液囊、提肛肌等脏器系数，和精子活动能力,以及给药后的雄性小鼠使雌性小鼠受孕的比例。结果 对氢化可的松造成的阳虚模型小鼠以及对大鼠去势肾阳虚模型，黄麦合剂各剂量应用后均能减轻阳虚程度，能够显著增加雄性大鼠精子数及精子生成量，不造成雄性大鼠生殖系统相关器官及腺体的增生，对大鼠的睾酮、精子畸形率及精子活力亦有明显改善作用。结论 黄麦合剂能明显改善氢化可的松造成的阳虚模型小鼠症状；对大鼠去势肾阳虚模型，黄麦合剂各剂量应用后均能减轻肾阳虚程度；黄麦合剂具有温和的生精作用，能显著提升雄性小鼠的生殖能力。

Objective To assess the effects of Huangmai mixture on the reproductive function of male rodents and protection of the model of yang deficiency. Methods The hydrocortisone-induced mouse model of yang deficiency and emasculation-caused rat model of kidney-yang deficiency were constructed. The rat serum testosterone level, organ coefficients of reproductive organs and glands such as prostate, sperm bladders, and levator ani muscle, sperm motility, and pregnancy rate of female mice were observed after administration of Huangmai mixture. Results For the hydrocortisone-induced mouse model of yang deficiency and emasculation-caused rat model of kidney-yang deficiency, different doses of Huangmai mixture could reduce the level of yang deficiency, significantly increase sperm counts and sperm production without causing the hyperplasia of reproductive organs and glands of male rats, significantly improve the testosterone level and sperm motility, and decrease the sperm abnormality rate of male rats. Conclusion Huangmai mixture can significantly alleviate the symptoms of hydrocortisone-induced mouse model of yang deficiency. For emasculation-caused rat model of kidney-yang deficiency, different doses of Huangmai mixture can reduce the level of kidney-yang deficiency. Huangmai mixture has a mild spermatogenic effect, which can significantly improve the reproductive capacity of male mice.