目的 观察坎地沙坦对慢性束缚应激（CRS）诱导的大鼠抑郁样行为的改善作用，探索抗抑郁治疗的新靶点。方法 雄性Wistar大鼠24只，随机分为3组：空白对照组（n=8）、束缚应激组（n=8）和坎地沙坦组（n=8）。通过旷场实验（OFT）、糖水偏爱实验（SPT）及强迫游泳实验（FST）评估大鼠抑郁样行为。用ELISA法检测血浆促肾上腺皮质激素（ACTH）及血管紧张素Ⅱ（AngⅡ）水平。结果 坎地沙坦组与应激组比较，OFT中直立次数及水平位移显著升高（P=0.000），SPT中对糖水偏好程度增加（P=0.027），FST中不动时间缩短（P=0.000），血浆ACTH明显下降（P=0.000）。结论 坎地沙坦可改善CRS诱导的大鼠抑郁样行为。

Objective To observe the effect of candesartan on improving chronic restraint stress (CRS)-induced depression-like behaviors in rats and explore novel targets for the treatment of depression. Methods Twenty-four male Wistar rats were randomly assigned to control group (n=8), stressed group (n=8), and candesartan group (n=8), respectively. Open field test (OFT), sucrose preference test (SPT), and forced swimming test (FST) were performed to evaluate depression-like behaviors in rats. ELISA was used to detect adrenocorticotropin hormone (ACTH) and aniotensin Ⅱ (AngⅡ) levels. Results Compared with the stressed group, rearing frequency and horizontal moving distance in OFT in the candesartan group significantly increased (P=0.000), sucrose preference percentage in SPT elevated (P=0.027), immobility time in FST reduced (P=0.000), and plasma ACTH level significantly decreased (P=0.000). Conclusion Candesartan can improve CRS-induced depression-like behaviors in rats.