口腔鳞状细胞乳头状瘤和乳头状癌的临床病理学分析
网络出版日期: 2016-05-26
Clinicopathologic analysis of oral squamous papilloma and papillary squamous cell carcinoma
1.Department of Stomatology, Branch of Shanghai First Peoples Hospital, Shanghai Jiao Tong University, Shanghai 200081, China; 2.Department of Oral Mucosal Diseases, Shanghai Ninth Peoples Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China; 3.Stomatology Special Consultation Clinic, Shanghai Ninth Peoples Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China
Online published: 2016-05-26
目的 分析口腔黏膜鳞状细胞乳头状瘤和乳头状癌患者的临床病理学特征。方法 对122例乳头状瘤(乳头状瘤组)和61例乳头状癌(乳头状癌组)患者的临床和病理学检查资料进行回顾性分析。比较2组患者的性别构成、年龄、病变部位及病理学特征。结果 2组患者均男性占多数。乳头状癌组发病年龄较高,其中吸烟10人(16.4%),有饮酒史11人(18.0%),病变多发于牙龈(占29.5%);乳头状瘤则多发于腭部(占46.7%)。组织学检查发现:乳头状癌表现为核多形性、伴异形有丝分裂象等恶性细胞学表现。免疫组织化学染色结果显示:在乳头状癌组织中,Ckpan、CK-HMW和p53蛋白呈阳性表达,CK8、Vim、SMA和S-100蛋白呈阴性表达。结论 牙龈乳头状肿物的老年患者是罹患乳头状癌的高风险群体,对该群体应采取积极的组织活检和病理学检查等早期诊治措施。
周淳 , 周曾同 , 张珺晔 , 郑元俐 . 口腔鳞状细胞乳头状瘤和乳头状癌的临床病理学分析[J]. 上海交通大学学报(医学版), 2016 , 36(4) : 550 . DOI: 10.3969/j.issn.1674-8115.2016.04.018
Objective To analyze clinicopathological characteristics in patients with oral squamous papilloma and papillary squamous cell carcinoma (PSCC). Methods Clinicopathological data of 122 patients with oral squamous papilloma and 61 patients with PSCC were retrospectively analyzed. Sex, age, lesion location, and pathological characteristics were compared between two groups. Results Most patients in both two groups were male. For the PSCC group, the average age was older as compared with the papilloma group. Ten patients (16.4%) had smoking history and 11 patients (18.0%) had drinking history in the PSCC group. Papilloma and PSCC were frequently occurred at palate (46.7%) and gingiva (29.5%), respectively. Histological examination found that PSCC had malignant cytological manifestations such as pleomorphic cells and abnormal mitotic figures. Immunohistochemical staining indicated that CKpan, CKhmw, and p53 proteins expressed positively in PSCC tissues, whereas CK8, Vim, SMA, and S-100 proteins expressed negatively. Conclusion Elderly patients with papillary lesions located at gingiva are high risk population of PSCC. Active early diagnosis and treatment measures, such as tissue biopsy and pathological examination, should be taken for this population.
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