LncRNAs在血管性疾病中的作用
网络出版日期: 2016-05-26
基金资助
国家自然科学基金(81000354);上海市自然科学基金(14ZR1427000)
Role of LncRNAs in vascular diseases
Online published: 2016-05-26
Supported by
National Natural Science Foundation of China, 81000354; Natural Science Foundation of Shanghai, 14ZR1427000
黄椿媚 , 王晓 , 葛勤敏 . LncRNAs在血管性疾病中的作用[J]. 上海交通大学学报(医学版), 2016 , 36(4) : 576 . DOI: 10.3969/j.issn.1674-8115.2016.04.023
Vascular diseases are a serious problem that threats human health with key pathological characteristics of aberrant proliferation of vascular smooth muscle cells and formation of neointimal lesions. Recent evidence has demonstrated that non-coding RNAs play an important role in the regulation of tissue homeostasis and pathophysiological conditions. Besides microRNAs (miRNAs), long non-coding RNAs (LncRNAs) contribute to gene expression and signaling pathway at various stages. Recently, LncRNAs have been identified to play a role in vascular development, lineage commitment, and mesoderm differentiation into heart and to be associated with angiotensin Ⅱ actions and vascular diseases, including heart diseases and atherosclerosis. LncRNAs may mediate many different pathways in vascular development and related diseases. This review mainly discusses the role of LncRNAs in vascular diseases.
Key words: long noncoding RNAs; vascular disease; vascular development
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