微小RNA参与心肌缺血再灌注损伤的研究新进展
网络出版日期: 2016-05-26
基金资助
上海市自然科学基金(13XDl403200)
New research progresses of micro-RNAs involving in myocardial ischemia reperfusion injury
Online published: 2016-05-26
Supported by
Natural Science Foundation of Shanghai, 13XDl403200
杨阳 , 刘益 , 丁芳宝 . 微小RNA参与心肌缺血再灌注损伤的研究新进展[J]. 上海交通大学学报(医学版), 2016 , 36(4) : 584 . DOI: 10.3969/j.issn.1674-8115.2016.04.025
Myocardial ischemia reperfusion injury (MIRI),which occurs after reperfusion of ischemic myocardium, presents a series of myocardial functional disorder and structural impairments. In recent years, researchers have found abnormal up-regulated or down-regulated expressions of many micro-RNAs (miRNAs) during the course of MIRI. By targeting specific genes, miRNAs can modulate downstream signaling pathways and cause changes in expressions of corresponding proteins, thus involve in the process of regulating MIRI. MIRI can be alleviated by up-regulating or down-regulating expressions of target miRNAs via technical approaches. As biomarkers of acute myocardial infarction, miRNAs can reflect the severity and prognosis of the disease. This paper reviews new research progresses of mechanisms and clinical applications of miRNAs in MIRI.
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