血管紧张素Ⅱ-2型受体在心血管疾病炎症反应中的作用
网络出版日期: 2016-05-26
基金资助
上海市科委医学引导项目(124119a2100)
Effects of angiotensin Ⅱ type-2 receptor on inflammatory reactions in cardiovascular diseases
Online published: 2016-05-26
Supported by
Medicine Guidance Project of Science and Technology Commission of Shanghai Municipality,124119a2100
杜明君 , 连锋 , 薛松 . 血管紧张素Ⅱ-2型受体在心血管疾病炎症反应中的作用[J]. 上海交通大学学报(医学版), 2016 , 36(5) : 772 . DOI: 10.3969/j.issn.1674-8115.2016.05.031
Most cardiovascular diseases are associated with chronic inflammatory reactions. The rennin angiotensin system (RAS) is involved in occurrence and development of the cardiovascular inflammation. The inflammatory effect of angiotensin Ⅱ (Ang II) is mainly achieved via the AngⅡ type-1 (AT1) receptor. However, Ang Ⅱ type-2 (AT2) receptor is less well understood as compared with AT1 receptor. Recent studies have found that AT2 receptor also participates in the inflammatory reaction process of many cardiovascular diseases. Stimulated AT2 receptor can inhibit the development of inflammation at different levels. This paper reviews mechanism of the involvement of AT2 receptor in regulating inflammatory reactions of cardiovascular system.
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