目的 探讨41 ℃及43 ℃温热疗（MH）触发聚乙二醇化脂质体阿霉素（PLD）释放阿霉素治疗兔VX2肿瘤的疗效差异。方法 12只VX2移植瘤兔随机分为2组：PLD+41 ℃ MH组(n=6)和PLD+43 ℃ MH组(n=6)。为达到完全的肿瘤缓解，进行多次高剂量耳缘静脉推注给药（5 mg/kg，每周1次，共治疗3次），使用嵌入式超声温热治疗仪对肿瘤部位进行30 min局部MH。结果 在观察终点，PLD+41 ℃ MH组血管形成指数（VI）、瘤体质量、外周血谷草转氨酶（GOT）、乳酸脱氢酶(LDH)、肌酸激酶(CPK)值均明显低于PLD+43 ℃ MH组。结论 同43 ℃下30 min MH相比，41 ℃下30 min MH联合PLD可以明显提高抗肿瘤疗效，降低系统毒性。

Objective To investigate the difference in efficacy between doxorubicin released by 41 ℃ and 43 ℃ mild hyperthermia (MH) triggered-pegylated liposomal doxorubicin (PLD) for the treatment of rabbit VX2 tumor. Methods Twelve rabbits with VX2 tumor transplanted into the superficial muscle of the hind limb were randomly assigned to 2 groups, i.e. the 41 ℃ MH+PLD group (n=6) and the 43 ℃ MH+PLD group (n=6). To achieve complete tumor remission, multiple high-dose administrations (5 mg/kg, once per week for 3 weeks) were given by intravenous injection. An embedded ultrasound tumor hyperthermia instrument was used to perform local MH at tumor sites for 30 min. Results At the endpoint, the 41 ℃ MH+PLD group had lower vascularization index, tumor weight, and levels of GOT, LDH and CPK in peripheral blood as compared with the 43 ℃ MH +PLD group. Conclusion In comparison with 43 ℃ MH for 30 min, 41 ℃ MH for 30 min plus PLD can significantly improve the antitumor efficacy, and reduce the systemic toxicity.