非编码RNA在多囊卵巢综合征中的作用研究进展
网络出版日期: 2016-07-25
基金资助
国家科技支撑计划(2012BAI32B00);国家自然科学基金(81450038)
Research advances in the roles of ncRNAs in polycystic ovary syndrome
Online published: 2016-07-25
Supported by
The National Key Technology R&D Program, 2012BAI32B00; National Natural Science Foundation of China, 81450038
杨倩 , 周承亮 , 潘洁雪 , 黄荷凤 . 非编码RNA在多囊卵巢综合征中的作用研究进展[J]. 上海交通大学学报(医学版), 2016 , 36(6) : 921 . DOI: 10.3969/j.issn.1674-8115.2016.06.027
Polycystic ovary syndrome (PCOS) is a common reproductive system disease affecting approximately 5% to 10% of women of childbearing age. The pathogenesis of PCOS remains unclear despite increasing studies in recent years. ncRNAs are RNAs not translating into proteins and mainly involve in many important functions such as regulation of gene expression and epigenetics. ncRNAs become a research hotspot recently. Previous studies have found changes in expressions of various ncRNAs in serum, follicle fluid, and granulosa cells of PCOS patients. It may be a new target for the diagnose of PCOS and provide new idea for studying the pathogenesis of PCOS. This paper reviews recent research advances in the roles of ncRNA in the occurrence and development of PCOS.
Key words: polycystic ovary syndrome; ncRNA; microRNA; lncRNA
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