综述

免疫球蛋白A肾病发病机制及相关血清标志物

  • 张沥文 ,
  • 王伟铭
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  • 上海交通大学 医学院附属瑞金医院肾脏科, 上海 200025
张沥文(1992—), 女, 博士生; 电子信箱: zhang.liwen92@foxmail.com。

网络出版日期: 2016-07-25

Pathogenesis and relevant serum biomarkers of immunoglobulin A nephropathy

  • ZHANG Li-wen ,
  • WANG Wei-ming
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  • Department of Nephrology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China

Online published: 2016-07-25

摘要

免疫球蛋白A(IgA)肾病是目前世界范围内最常见的原发性肾小球疾病。糖基化缺陷的IgA1分子引起自身免疫反应,是IgA肾病发病的始动机制。近年来,在IgA肾病发病机制和标志物方面的研究取得了显著进展,这为IgA肾病的非侵入性诊断、疾病活动监测和疾病特异性治疗提供了基础。该文就IgA肾病发病的分子机制和重要血清标志物的研究进展作一综述。

本文引用格式

张沥文 , 王伟铭 . 免疫球蛋白A肾病发病机制及相关血清标志物[J]. 上海交通大学学报(医学版), 2016 , 36(6) : 939 . DOI: 10.3969/j.issn.1674-8115.2016.06.031

Abstract

Immunoglobulin A (IgA) nephropathy is the most prevalent primary chronic glomerular disease worldwide. The autoimmune response caused by galactose-deficient polymeric IgA1 is the original mechanism triggering the IgA nephropathy. Significant research advances in pathogenesis and biomarkers of IgA nephropathy have been made in recent years and provide the basis for noninvasive diagnosis, monitoring of disease activity, and disease-specific therapies. The research advances in molecular mechanisms and key serum biomarkers in the pathogenesis of IgA nephropathy are reviewed in this paper.

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