论著(临床研究)

残余胆固醇在急性冠脉综合征患者评估中的应用

  • 汪萍 ,
  • 毛剑虹 ,
  • 陆一闻 ,
  • 沈立松
展开
  • 上海交通大学 医学院附属新华医院检验科,上海 200092
汪萍(1974—),女,副主任技师,硕士;电子信箱:pink_wangping@163.com。

网络出版日期: 2016-12-29

基金资助

上海市科委生物医药领域产学研医合作项目(14DZ1940200, 14DZ1940203)

Application of residual cholesterol to the assessment of patients with acute coronary syndrome

  • WANG Ping ,
  • MAO Jian-hong ,
  • LU Yi-wen ,
  • SHEN Li-song
Expand
  • Department of Laboratory Medicine, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200092, China

Online published: 2016-12-29

Supported by

Production-Study-Research-Medical Cooperation Science and Technology Commission of Shanghai Municipality, 14DZ1940200, 14DZ1940203

摘要

目的 ·研究残余胆固醇(RC)水平对急性冠脉综合征(ACS)患者的临床应用评估。方法 ·利用生化法检测293例稳定型心绞痛患者、115例非高血压的ACS患者、72例合并高血压的ACS患者、91例疾病对照组患者和152例表观健康人群的总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-Ch)和低密度脂蛋白胆固醇(LDL-Ch)水平。RC由TC减去HDL-Ch和LDL-Ch得到,非高密度脂蛋白胆固醇(non-HDL-Ch)由TC减去HDL-Ch得到。对RC与TC、LDL-Ch、HDL-Ch、non-HDL-Ch的相关性进行分析。利用ROC曲线分析RC、LDL-Ch、non-HDL-Ch在鉴别稳定型心绞痛组和ACS中的作用。结果 · ACS组、ACS合并高血压组的RC均显著高于稳定型心绞痛组(P<0.05)。RC与TC、LDL-Ch、HDL-Ch和non-HDL-Ch相关性均有统计学意义(均P<0.01)。稳定型心绞痛及ACS患者的ROC曲线分析表明, RC对于鉴别该2种疾病最佳,以下依次为non-HDL-Ch、LDL-Ch、TC、HDL-Ch。结论 · RC水平在缺血性心脏病患者中明显升高,可作为ACS与稳定型心绞痛的鉴别指标。

本文引用格式

汪萍 , 毛剑虹 , 陆一闻 , 沈立松 . 残余胆固醇在急性冠脉综合征患者评估中的应用[J]. 上海交通大学学报(医学版), 2016 , 36(12) : 1750 . DOI: 10.3969/j.issn.1674-8115.2016.12.014

Abstract

Objective · To investigate the clinical application of serum remnant cholesterol (RC) to the assessment of patients with acute coronary syndrome (ACS). Methods · We enrolled 293 patients with stable angina (SA), 115 patients with non-hypertensive ACS, 72 patients with hypertensive ACS, 91 patients as controls, and 152 healthy controls. Levels of total cholesterol (TC), HDL- cholesterol (HDL-Ch), and LDL-Ch were measured with biochemistry method. RC was given by subtracting LDL-Ch and HDL-Ch from TC and non-HDL-Ch was given by subtracting HDL-Ch from TC. The correlations of RC with TC, LDL-Ch, HDL-Ch, and non-HDL-Ch were analyzed. ROC curves were used to analyze the application of RC, LDL-Ch, HDL-Ch, and non-HDL-Ch for differentiating SA and ACS. Results · The RC level was significantly higher in the ACS group and the hypertensive ACS group than in the SA group (P<0.05). Correlations of RC with TC, LDL-Ch, HDL-Ch, and non-HDL-Ch were statistically significant (P<0.01). The ROC curve analysis showed that RC was the best for differentiating SA and ACS, followed by non-HDL-Ch, LDL-Ch, TC, and HDL-Ch. Conclusion · Remnant cholesterol is significantly elevated in the patients with ischemic heart disease and can be used for differentiating ACS and stable angina.

文章导航

/