细胞膜脂质主要包括鞘脂类、甘油磷脂类以及固醇类3种，它们在大脑中含量丰富且广泛。目前已有许多研究发现了机体中膜脂质类的代谢紊乱参与了阿尔茨海默病（AD）的病理生理，尤其与β淀粉样蛋白(Aβ)及其相关代谢酶异常息息相关。该文针对AD病程中涉及的膜脂改变与Aβ异常相关的研究作一综述，从细胞膜脂质代谢的角度为AD相关发病机制的研究提供新的视角和思路。

Membrane lipids mainly include sphingolipid, glycerophospholipid, and cholesterol, which are abundant in brain. Currently, lots of researches have indicated that metabolic disturbance of membrane lipids in body is associated with pathophysiology in Alzheimer’s disease (AD), especially with abnormalities of amyloid β (Aβ) and its relevant metabolic enzyme. This article aims to review studies on the association of changes of membrane lipids with Aβ abnormality and provides new views and ideas for studies on the pathogenesis of AD from the perspective of membrane lipids metabolism.