肠道菌群与大脑双向互动的研究进展
网络出版日期: 2017-02-28
基金资助
国家自然科学基金(31501079)上海市科委青年科技英才扬帆计划(15YF1409100);上海市第六人民医院院级科学研究基金(YNLC201421)
Research progress of the bidirectional interaction between gut microbiota and brain
Online published: 2017-02-28
Supported by
National Natrual Science Foundation of China, 31501079; Sail Plan of Shanghai Youth Science and Technology Talents of Science and Technology Commission of Shanghai Municipality, 15YF1409100; Scientific Research Fund of Shanghai Sixth People’s Hospital, YNLC201421
游懿君 , 韩小龙 , 郑晓皎 , 赵爱华 , 陈天璐 . 肠道菌群与大脑双向互动的研究进展[J]. 上海交通大学学报(医学版), 2017 , 37(2) : 253 . DOI: 10.3969/j.issn.1674-8115.2017.02.025
The gut-brain axis (GBA) is a nerve-endocrine mediated bidirectional communication system between the gut and brain, which links the cognition and emotion in brain to peripheral intestinal function. In recent years, many researches have showed that colonized intestinal microbiota plays an important role in the communication between gut and brain. On one hand, microbiota can influence the development and function of brain via GBA. On the other hand, brain can also change the composition of gut microbiota. These findings gradually become a novel medical research highlight, i.e. the microbiota-gut-brain axis. This paper reviews the interaction between gut microbiota and brain via GBA in order to provide supports for studying functions of gastrointestinal tract and brain, as well as the treatment of related diseases.
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