蛋白质精氨酸甲基转移酶在肿瘤中的作用及机制研究进展
网络出版日期: 2017-07-05
基金资助
国家自然科学基金(81372195,81572719);上海市教育委员会高峰高原学科建设计划(20152516)
Research progress of effect and mechanism of protein arginine methyltransferase in tumors
Online published: 2017-07-05
Supported by
National Natural Science Foundation of China, 81372195, 81572719; Shanghai Municipal Education Commission—Gaofeng Clinical Medicine Grant Support, 20152516
蛋白质精氨酸甲基转移酶(PRMT) 能甲基化多种蛋白,包括组蛋白和非组蛋白,影响多种细胞过程,如转录、RNA 剪接、 DNA 修复、细胞周期的控制等。PRMT 的活性受多种调节机制影响,它的异常表达在疾病的发生发展中起重要作用,尤其是肿瘤, 如乳腺癌、白血病等。PRMT 在肿瘤诊断或治疗中有着独特的价值。随着 PRMT 甲基化机制的深入探索,目前 PRMT 选择性抑制剂 的研究已取得一定进展,PRMT 特异性抑制剂有望成为治疗肿瘤的精准靶向药物。
关键词: 蛋白质精氨酸甲基转移酶; 甲基化; 肿瘤
文君 , 闵雪洁 , 赵丽 , 赵小平 . 蛋白质精氨酸甲基转移酶在肿瘤中的作用及机制研究进展[J]. 上海交通大学学报(医学版), 2017 , 37(6) : 842 . DOI: 10.3969/j.issn.1674-8115.2017.06.022
Protein arginine methyltransferase (PRMT) can methylate a variety of proteins, including histones and non-histones, affecting a variety of cellular processes such as transcription, RNA splicing, DNA repair, and cell cycle control. The activity of PRMT is affected by a variety of regulatory mechanisms, and its abnormal expression plays an important role in the development of the diseases, especially in tumors such as breast cancer and leukemia. PRMT has a unique value in the diagnosis or treatment of tumors. With the further exploration of PRMT methylation mechanism, PRMT selective inhibitors have made some progress. PRMT-specific inhibitors are expected to be targeted drugs for the treatment of tumors.
Key words: PRMT; methylation; tumor
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