上海交通大学学报（医学版）

上海交通大学学报（医学版） >

2017 , Vol. 37 >Issue 6: 865

DOI: https://doi.org/10.3969/j.issn.1674-8115.2017.06.026

综述

转录因子 C/EBPβ在子宫蜕膜化中的作用及机制研究进展

  • 狄芳芳 ,
  • 刘建胜 ,
  • 李尚 ,
  • 杜艳芝
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  • 上海交通大学 医学院附属仁济医院生殖医学中心，上海市辅助生殖与优生重点实验室，上海 200135
狄芳芳（1991—），女，硕士生；电子信箱：dfffang@163.com

网络出版日期: 2017-07-05

基金资助

上海市教育委员会高峰高原学科建设计划（20152510）

收起

Progress on roles and mechanisms of CCAAT/enhancer binding protein β in endometrium decidualization

  • DI Fang-fang ,
  • LIU Jian-sheng ,
  • LI Shang ,
  • DU Yan-zhi
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  • Shanghai Key Laboratory for Assisted Reproduction and Reproductive Genetics, Center for Reproductive Medicine, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200135, China

Online published: 2017-07-05

Supported by

Shanghai Municipal Education Commission—Gaofeng Clinical Medicine Grant Support, 20152510

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摘要

 CCAAT 增强子结合蛋白 β（C/EBPβ）是 CCAAT 增强子结合蛋白家族的重要成员。C/EBPβ蛋白可通过其羧基端 bZIP 结构域调控 下游靶基因的转录活性，进而参与细胞的增殖、分化等生命活动。近期研究显示，C/EBPβ在子宫内膜基质细胞的蜕膜化过程中具有重要 的调控作用。该文就近年来 C/EBPβ在子宫内膜基质细胞蜕膜化中的作用及机制进行综述，旨在为临床蜕膜化障碍研究提供新的视角。

关键词：   CCAAT 增强子结合蛋白 β 子宫内膜基质细胞; 蜕膜化; 增殖; 分化; 细胞周期

本文引用格式

狄芳芳 , 刘建胜 , 李尚 , 杜艳芝 . 转录因子 C/EBPβ在子宫蜕膜化中的作用及机制研究进展[J]. 上海交通大学学报（医学版）, 2017 , 37(6) : 865 . DOI: 10.3969/j.issn.1674-8115.2017.06.026

Abstract

 CCAAT/enhancer binding protein β (C/EBPβ) is a critical member of C/EBP family. C/EBPβ, based on the leucine zipper located in C terminal of the protein, can regulate transcriptional activities of downstream target genes involved in diverse cellular processes, such as proliferation and differentiation. Recently published studies have identified that C/EBPβ is essential in the decidualization of endometrial stromal cells. This review summarizes the roles and mechanisms of C/EBPβ during the courses of decidualization, which is aimed at providing novel insights for dysfunctional decidualization.

Key words： CCAAT/enhancer binding protein β; endometrial stromal cell; decidualization; proliferation; differentiation; cell cycle

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