目的 · 探讨高龄食管癌患者手术治疗预后的影响因素。方法 · 收集 103 例高龄(≥ 80 岁)食管癌且接受手术治疗患者的临床 资料。分析患者性别、年龄、临床表现、术前伴随疾病、术后并发症、肿瘤 T 分期、淋巴结转移情况、肿瘤最长径、肿瘤发生部位及 手术方式等因素对患者术后生存期的影响。结果 · 103 例患者的术后 1、3、5 年生存率分别为 63.2%、15.9%、2.7%。Kaplan–Meier 法 生存曲线分析显示:肿瘤 pT 分期为 T1、T2 期患者的术后生存期明显优于 T3 期患者,其中 pT1 分期患者 3、5 年生存率分别为 50%、 25%。Cox 回归多因素分析结果显示,影响术后生存的独立因素为肿瘤pT 分期、肿瘤最长径、术后并发症和淋巴结转移情况。结 论 · 对于 80 岁以上的高龄食管癌患者,肿瘤最长径小、术后并发症少且无淋巴结转移患者的术后生存期较长,选择T 分期相对更早 (T1、T2)的患者实施手术治疗可以获得较为理想的术后生存期。
Objective · To investigate factors affecting the prognosis of aged esophageal cancer patients after esophagectomy. Methods · Clinical data of 103 aged patients ( ≥ 80 years old) undergoing esophagectomy were collected. Effects of age, sex, clinical manifestations, pre-operative diseases, postoperative complications, T stage, lymph node metastasis, maximum diameter and location of the tumor, and surgical methods on the post-operative survival were analyzed. Results · 1, 3, and 5 years survival rates of 103 patients were 63.2%, 15.9%, and 2.7%, respectively. Kaplan–Meier survival curve analysis indicated that the post-operative survival was significantly higher in patients with T1 and T2 stages than in patients with T3 stage. The 3 and 5 y survival rates of patients with T1 stage were 50% and 25%, respectively. Results of Cox regression multivariate analysis showed that T stage, maximum diameter of tumor, postoperative complications, and lymph node metastasis were independent factors affecting the post-operative survival. Conclusion · Esophageal cancer patients aged over 80 years with smaller tumor diameters, less postoperative complications, and negative lymph node metastasis have a longer postoperative survival period. Esophagectomy for patients with earlier stages (T1 and T2) can achieve an ideal post-operative survival period.