目的 · 探讨二甲双胍对奥氮平灌胃大鼠胰岛素抵抗相关代谢参数的改善作用。方法 · 将 30 只雌性 SD 大鼠随机分为二甲双胍 干预组、奥氮平组和生理盐水对照组。第1 ～ 6 周，前 2 组给 5 mg/(kg · d) 奥氮平、第 3 组给等量生理盐水进行灌胃。第7 周开始， 干预组合用二甲双胍 500 mg/(kg · d)，奥氮平组合用等量生理盐水，继续灌胃 4 周。6 周末及 10 周末评估腹腔葡萄糖耐量和胰岛素抵 抗指数。结果 · 6 周末，干预组及奥氮平组腹腔葡萄糖耐量曲线下面积（P=0.040）、胰岛素抵抗指数（P=0.000）显著高于对照组。10 周末时，干预组糖耐量（P=0.015）及胰岛素抵抗指数明显低于奥氮平组（P=0.001）。 结论 · 二甲双胍治疗可以纠正奥氮平引起的糖耐 量受损，部分改善胰岛素抵抗。

Objective · To investigate the effect of metformin on insulin resistance (IR)-related metabolic parameters in olanzapine-bearing rats.  Methods · Thirty female SD rats were randomly divided into metformin intervention group, olanzapine group and control group. During the first 6 weeks, 5 mg /(kg·d) olanzapine was given to the two test groups . The control group was given the same amount of saline. From the 7th week, the intervention group began to combine with metformin 500 mg / (kg·d), while the olanzapine group combined with the same amount of saline, continuing  for 4 weeks. At the end of 6th week and 10th week, intraperitoneal glucose tolerance and homeostasis model assessment IR index were assessed.  Results · The area under the glucose tolerance curve (P=0.040) and the IR index (P=0.000) were significantly higher for the intervention group and the olanzapine group than the control group at the end of 6th week. At the 10th weekend, the glucose tolerance (P=0.015) and IR index in the intervention group were significantly lower than those in the olanzapine group (P=0.001).  Conclusion · Metformin may rectify the impaired glucose tolerance and improve IR induced by olanzapine partly.