自噬在维持正常血管结构功能中提供保护功效，但过度自噬可能导致高血压病等血管疾病的发病。血管自噬失衡参与高血压 血管重构损伤的发生和发展，且与 ACE2/Apelin 信号表达或活性异常密切相关。该文主要对 ACE2/Apelin 信号参与血管自噬调控及其 在高血压发病过程中的作用作一综述。

 Autophagy provides protective effects on the maintenance of normal vascular structure and function. However, an overactivation of autophagy contributes to the pathogenesis of hypertension and other vascular diseases. The imbalance of vascular autophagy is involved in the occurrence and development of hypertensive vascular remodeling and injury, which is closely related to abnormal expression or activity of ACE2/Apelin signaling. This review will focus on the latest advancement and regulatory roles of ACE2/Apelin signaling in vascular autophagy and the pathogenesis of hypertension.