目的 · 分析绝经前后子宫内膜癌患者的临床及病理特点。方法 · 回顾性分析2013 年 12 月—2017 年 3 月上海交通大学医学 院附属瑞金医院52 例绝经前和 150 例已绝经子宫内膜癌患者的临床病理资料。结果 · 未绝经组合并高血压比例为28.8%，显著低于 绝经组（P<0.01）；未绝经组的组织学分级G3 比例为8.3%，伴深肌层浸润比例为13.5%，均显著低于绝经组（P<0.05）；未绝经组 累及卵巢比例高达17.6%，显著高于绝经组（P<0.05）。 2 组病例在合并肥胖或糖尿病、CA125、CA199、手术- 病理分期、病理类 型、脉管浸润、淋巴结转移等方面差异无统计学意义。结论 · 未绝经的子宫内膜癌患者肿瘤恶性程度相对较低，但累及卵巢的概率 更大。

Objective · To analyze the clinical and pathological characteristics of endometrial carcinoma patients before and after menopause.  Methods · Fifty-two premenopausal cases and 150 postmenopausal cases with endometrial carcinoma from December 2013 to March 2017 in Ruijin Hospital, Shanghai Jiao Tong University School of Medicine were retrospectively analyzed.   Results · The ratio of patients with hypertension in premenopausal group was 28.8%, which was significantly lower than that in postmenopausal group (P<0.01). In premenopausal group, the proportion of G3 in histological grading was 8.3%, and the ratio of deep myometrial invasion was 13.5%, all of which were significantly lower than those of postmenopausal group (P<0.05). The ratio of ovarian involvement was as high as 17.6%, which was significantly higher than that of postmenopausal group (P<0.05). There were no significant differences between the two groups in other clinical-pathological parameters such as obesity, diabetes, CA125, CA199, surgical-pathological staging, pathological type, vascular involvement, and lymph node metastasis.  Conclusion · Premenopausal endometrial carcinoma is less malignant, while the probability of ovarian involvement is higher.