收稿日期: 2020-02-14
网络出版日期: 2021-02-28
基金资助
国家重点研发计划(2018YFC1314302);国家自然科学基金(81471358);上海市科学技术委员会西医引导类项目(19411969300);上海市教育委员会高峰高原学科建设计划(20152530)
Research advances in inflammatory mechanism of anhedonia
Received date: 2020-02-14
Online published: 2021-02-28
Supported by
National Key Research and Development Program of China(2018YFC1314302);National Natural Science Foundation of China(81471358);Western Medicine Guide Project of Science and Technology Commission of Shanghai Municipality(19411969300);Shanghai Municipal Education Commission—Gaofeng Clinical Medicine Grant Support(20152530)
吴则南 , 张晨 . 快感缺失的炎症机制研究进展[J]. 上海交通大学学报（医学版）, 2021 , 41(2) : 241 -245 . DOI: 10.3969/j.issn.1674-8115.2021.02.018
Anhedonia, a typical symptom of many mental diseases, is also an important indicator for treatment outcome. Further exploration of the mechanism of anhedonia and clear definition and illustration of its pathophysiological basis are helpful to the diagnosis and treatment of related diseases. In recent years, converging evidence has implicated that inflammation-driven alterations in kynurenine pathway (KP) and tetrahydrobiopterin (BH4) metabolism lead to nerve injury and disturbance of neurotransmitter in reward circuit, which is closely related to the emergence and development of anhedonia. Therefore, this review aims to summarize the research advances in the inflammatory mechanism of anhedonia, with the emphasis on both KP and BH4 metabolism.
Key words： anhedonia; reward circuit; inflammation; kynurenine pathway; tetrahydrobiopterin
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