上海交通大学学报（医学版）

上海交通大学学报（医学版） >

2021 , Vol. 41 >Issue 6: 830 - 833

DOI: https://doi.org/10.3969/j.issn.1674-8115.2021.06.022

综述

ATP结合盒蛋白G超家族成员2在肺癌中的表达及意义

  • 徐建华 ,
  • 江萍 ,
  • 邓炯
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  • 1.昆明医科大学病理学与病理生理学系，昆明 650032
    2.上海交通大学基础医学院病理生理系细胞分化与凋亡教育部重点实验室，上海 200025
徐建华（1992—），女，硕士生；电子信箱：2283132073@qq.com。

网络出版日期: 2021-06-29

基金资助

国家自然科学基金(81620108022)

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Expression and significance of ATP-binding cassette superfamily G member 2 in lung cancer

  • Jian-hua XU ,
  • Ping JIANG ,
  • Jiong DENG
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  • 1.Department of Pathology and Pathophysiology, Kunming Medical University, Kunming 650032, China
    2.Key laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Department of Pathophysiology, Shanghai Jiao Tong University College of Basic Medical Sciences, Shanghai 200025, China

Online published: 2021-06-29

Supported by

National Natural Science Foundation of China(81620108022)

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摘要

肺癌细胞的干性及耐药性是重要的恶性指标。ATP结合盒蛋白G超家族成员2（ATP-binding cassette superfamily G member 2，ABCG2）是细胞表面的ATP结合盒蛋白家族的成员之一，依赖ATP可将药物排到细胞外。ABCG2定位于人多种肿瘤细胞的膜上，它的表达与肿瘤化学治疗多药耐药性紧密相关，目前被认为是肺癌干细胞鉴定的辅助群体标志物。此外，ABCG2的一些单核苷酸多态性与肺癌多药耐药性存在显著相关性。该文就最新ABCG2相关研究进展进行总结和归纳，重点介绍ABCG2基因的表达调控、ABCG2与肺癌干性的关系以及ABCG2的单核苷酸多态性与肺癌耐药性的相关性研究，以期为肺癌患者的临床治疗提供新的策略。

关键词： ATP结合盒蛋白G超家族成员2; 肺癌; 细胞干性; 耐药性

本文引用格式

徐建华 , 江萍 , 邓炯 . ATP结合盒蛋白G超家族成员2在肺癌中的表达及意义[J]. 上海交通大学学报（医学版）, 2021 , 41(6) : 830 -833 . DOI: 10.3969/j.issn.1674-8115.2021.06.022

Abstract

The stemness and drug resistance of lung cancer cells are important features of malignancy. ATP-binding cassette superfamily G member 2 (ABCG2), a member of the ATP-binding cassette transporter family, is localized in the membrane of a variety of human cancer cells and excludes drugs from cells in an ATP-dependent manner. Single nucleotide polymorphisms in ABCG2 gene are significantly associated with multidrug resistance in cancer chemotherapy. In addition, ABCG2 has been used as a supporting biomarker for the identification of lung cancer stem cells. This review summarizes recent research progress in ABCG2, focusing on the regulation of ABCG2 gene expression, the potential roles of ABCG2 on cancer cell stemness, and the correlation of single nucleotide polymorphisms in ABCG2 with drug resistance in lung cancer, in order to provide a new strategy for the clinical treatment of lung cancer patients.

Key words： ATP-binding cassette superfamily G member 2 (ABCG2); lung cancer; stemness; drug resistance

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