上海交通大学学报（医学版）

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2021 , Vol. 41 >Issue 7: 963 - 966

DOI: https://doi.org/10.3969/j.issn.1674-8115.2021.07.019

综述

Janus激酶抑制剂在特应性皮炎治疗中的临床应用研究进展

  • 庄昊俊 ,
  • 郭美亮 ,
  • 刘婉雯 ,
  • 邓辉
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  • 上海交通大学附属第六人民医院皮肤科，上海 200233
庄昊俊（1997—），男，硕士生；电子信箱：nichijou@sjtu.edu.cn。

网络出版日期: 2021-08-03

基金资助

国家自然科学基金(81673054)

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Clinical research progress of Janus kinase inhibitors in the treatment of atopic dermatitis

  • Hao-jun ZHUANG ,
  • Mei-liang GUO ,
  • Wan-wen LIU ,
  • Hui DENG
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  • Department of Dermatology, Shanghai Sixth People's Hospital, Shanghai Jiao Tong University, Shanghai 200233, China

Online published: 2021-08-03

Supported by

National Natural Science Foundation of China(81673054)

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摘要

特应性皮炎是一种慢性炎症性皮肤病，主要与Th2型信号通路的变化有关。白细胞介素-4（interleukin-4，IL-4）和IL-13的表达增加使聚丝蛋白减少，从而导致皮肤屏障缺陷。Janus激酶-信号转导及转录激活因子（Janus kinase-signal transducer and activator of transcription，Jak-STAT）信号通路与特应性皮炎的发病机制密切相关，抑制Jak-STAT信号通路治疗特应性皮炎是一种有潜力的方法。Janus激酶（Janus kinase，JAK）抑制剂在对JAKs抑制的选择上可分为第一代JAK抑制剂和第二代JAK抑制剂。该综述通过对第一代和第二代JAK抑制剂在临床试验中的疗效和安全性进行总结，阐明JAK抑制剂在特应性皮炎治疗中的临床应用研究进展。

关键词： 特应性皮炎; Jak-STAT信号通路; JAK抑制剂

本文引用格式

庄昊俊 , 郭美亮 , 刘婉雯 , 邓辉 . Janus激酶抑制剂在特应性皮炎治疗中的临床应用研究进展[J]. 上海交通大学学报（医学版）, 2021 , 41(7) : 963 -966 . DOI: 10.3969/j.issn.1674-8115.2021.07.019

Abstract

Atopic dermatitis is a chronic inflammatory skin disease, which is mainly related to changes in Th2 type signaling pathways. Increased expression of interleukin-4 (IL-4) and IL-13 reduces filaggrin, which leads to skin barrier defects. The Janus kinase-singal transducer and activator of transcriprion (Jak-STAT) signaling pathway is closely related to the pathogenesis of atopic dermatitis. Inhibiting the Jak-STAT signaling pathway is a potential method to treat atopic dermatitis. Janus kinase (JAK) inhibitors can be divided into first-generation and second-generation JAK inhibitors in the selection of JAKs′ inhibition. By summarizing the efficacy and safety of the first-generation and second-generation JAK inhibitors in clinical trials, the clinical research progress of JAK inhibitors in the treatment of atopic dermatitis is clarified.

Key words： atopic dermatitis; Jak-STAT signaling pathway; JAK inhibitors

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