网络出版日期: 2021-07-28
基金资助
国家自然科学基金面上项目(81871906);上海市领军人才(2017274)
Review of immunosuppressive tumor microenvironment of pancreatic cancer
Online published: 2021-07-28
Supported by
General Program of National Natural Science Foundation of China(81871906);Shanghai Leading Talents(2017274)
胰腺癌是一种高度恶性的肿瘤，早期诊断困难且缺乏有效的治疗方法，导致预后极差。胰腺癌肿瘤微环境包含肿瘤细胞、免疫细胞、基质细胞、细胞外基质以及多种可溶性分子；其中，细胞外成分包括基质成分和可溶性因子等，在肿瘤的发生、发展、侵袭和转移过程中发挥重要作用。胰腺癌微环境中具有显著的免疫细胞浸润，以免疫抑制为突出特征。肿瘤细胞一方面编辑免疫系统，使其无法被免疫系统识别；另一方面招募和激活各种免疫抑制性细胞如胰腺星状细胞、髓系来源抑制细胞、肿瘤相关巨噬细胞和调节性T细胞等，进而分泌免疫抑制性分子，影响抗肿瘤免疫细胞的功能，抑制宿主的抗肿瘤免疫反应，造成肿瘤的免疫逃逸，促进肿瘤的发展转移。该文讨论胰腺癌肿瘤微环境各种免疫抑制成分的作用机制，并总结胰腺癌免疫治疗的最新成果，以期为胰腺癌免疫抑制性肿瘤微环境的研究以及胰腺癌的免疫治疗提供新的思路。
李静威 , 王俐文 , 蒋玲曦 , 詹茜 , 陈皓 , 沈柏用 . 胰腺癌免疫抑制性肿瘤微环境研究综述[J]. 上海交通大学学报（医学版）, 2021 , 41(8) : 1103 -1108 . DOI: 10.3969/j.issn.1674-8115.2021.08.018
Pancreatic cancer is a highly malignant tumor. The difficulty of early diagnosis and scarcity of effective clinical treatment strategies lead to poor prognosis. Tumor microenvironment (TME) of pancreatic cancer is composed of tumor cells, immune cells, stromal cells, extracellular matrix and soluble factors. TME plays an important role in the development, progression, invasion and metastasis of tumors. The pancreatic cancer microenvironment has significant immune cell infiltration, which is highly immunosuppressive. On the one hand, tumor cells edit the immune system so that cancer cells cannot be recognized by the immune system; on the other hand, they can recruit and activate various immunosuppressive cells such as pancreatic stellate cells, myeloid-derived inhibitory cells, tumor-associated macrophages, regulatory T cells and so on. These immunosuppressive cells can secrete immunosuppressive molecules, affect the function of anti-tumor immune cells, inhibit the host′s anti-tumor immune response, lead to tumor immune escape, and promote tumor development and metastasis. In this review, the mechanisms and effects of these immunosuppressive components are discussed and the updated results of immunotherapy on pancreatic cancer are studied, which may provide novel insights on TME and immunotherapy of pancreatic cancer.
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