上海交通大学学报（医学版）

上海交通大学学报（医学版） >

2021 , Vol. 41 >Issue 9: 1261 - 1266

DOI: https://doi.org/10.3969/j.issn.1674-8115.2021.09.020

综述

孕期暴露邻苯二甲酸酯对胎盘功能的影响及其机制研究进展

  • 张前龙 ,
  • 田英
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  • 1.上海交通大学医学院附属新华医院环境与儿童健康教育部和上海市重点实验室，上海 200092
    2.上海交通大学公共卫生学院，上海 200025
张前龙（1979—），男，副主任技师，硕士；电子信箱：zhangql7989@163.com。
田英，电子信箱：tianmiejp@sjtu.edu.cn。

收稿日期: 2020-07-16

  网络出版日期: 2021-08-09

基金资助

上海交通大学医工交叉基金(YG2019ZDA29)

收起

Progress in the influence of prenatal exposure to phthalates on placental function and its mechanism

  • Qian-long ZHANG ,
  • Ying TIAN
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  • 1.MOE and Shanghai Key Laboratory of Children′s Environmental Health, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200092, China
    2.School of Public Health, Shanghai Jiao Tong University, Shanghai 200025, China
TIAN Ying, E-mail: tianmiejp@sjtu.edu.cn.

Received date: 2020-07-16

  Online published: 2021-08-09

Supported by

Medicine and Engineering Interdisciplinary Research Fund of Shanghai Jiao Tong University(YG2019ZDA29)

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摘要

邻苯二甲酸酯（phthalates，PAEs）在生活中广泛存在，是一类典型的环境内分泌干扰物（environmental endocrine disruptors，EEDs）。胎盘富含激素受体，使其对EEDs高度敏感。孕期暴露于PAEs，其代谢物可以透过胎盘，通过干扰激素受体影响胎盘功能。胎盘功能障碍将导致胎儿生长受限，甚至引起胎儿死亡。孕期PAEs暴露与胎盘功能异常相关的机制包括侵润/融合、氧化应激、细胞分化/凋亡、激素分泌和脂质积累等。该文总结了孕期PAEs暴露水平概况，综述PAEs对胎盘功能的影响及相关研究进展，并探讨当前研究可能存在的局限性，为未来深入研究PAEs影响胎盘功能的分子机制提供参考。

关键词： 邻苯二甲酸酯; 环境内分泌干扰物; 孕期暴露; 胎盘功能障碍

本文引用格式

张前龙 , 田英 . 孕期暴露邻苯二甲酸酯对胎盘功能的影响及其机制研究进展[J]. 上海交通大学学报（医学版）, 2021 , 41(9) : 1261 -1266 . DOI: 10.3969/j.issn.1674-8115.2021.09.020

Abstract

Phthalates (PAEs) are widespread in life and are a class of environmental endocrine disruptors (EEDs). The abundance of hormone receptors makes the placenta highly sensitive to EEDs. During pregnancy, women can be exposed to PAEs, and their metabolites can pass through the placenta and affect its function by interfering with hormone receptors.The dysfunction of placenta will result in fetal growth restriction or, if more severe, fetal death. Functional placental disruptions linked to phthalates exposures include invasion/migration, oxidative stress, cell differentiation/apoptosis, hormone secretion and lipid accumulation.In this paper, the exposure level of PAEs during pregnancy is summarized, the mechanism for the effect of phthalates on placenta is reviewed, and the possible limitations of these studies are discussed, aiming to provide insights for further studies on the potential molecular mechanism through which PAEs disrupt placental function.

Key words： phthalate (PAE); environmental endocrine disruptor (EED); prenatal exposure; placental dysfunction

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