上海交通大学学报（医学版）

上海交通大学学报（医学版） >

2021 , Vol. 41 >Issue 10: 1394 - 1396

DOI: https://doi.org/10.3969/j.issn.1674-8115.2021.10.020

综述

雌激素及其受体影响胆固醇结石形成的研究进展

  • 庄谦 ,
  • 董志霞 ,
  • 宛新建
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  • 上海交通大学附属第六人民医院消化内镜中心，上海 200233
庄 谦（1992—），男，博士生；电子信箱：mdzhuangqian@163.com。
宛新建，电子信箱：slwanxinjian2020@126.com。

网络出版日期: 2021-09-22

基金资助

上海市科技创新行动计划(19411951500)

收起

Research progress of effect of estrogen and its receptors on cholesterol gallstone disease

  • Qian ZHUANG ,
  • Zhi-xia DONG ,
  • Xin-jian WAN
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  • Digestive Endoscopic Center, Shanghai Sixth People's Hospital, Shanghai Jiao Tong University, Shanghai 200233, China
WAN Xin-jian, E-mail: slwanxinjian2020@126.com.

Online published: 2021-09-22

Supported by

Shanghai Science and Technology Innovation Action Plan(19411951500)

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摘要

胆固醇结石是消化系统常见病、多发病。胆汁中胆固醇过饱和及胆囊收缩功能障碍是胆固醇结石形成的重要病理生理机制。雌激素及其受体可通过调节胆固醇和胆汁酸代谢及胆囊收缩功能等机制影响胆固醇结石的形成。经典核受体（如雌激素受体α、雌激素受体β）以及新型膜受体（如G蛋白偶联受体30）在胆固醇结石形成中均发挥重要作用。针对雌激素受体设计合成选择性拮抗剂可能是潜在的胆固醇结石防治策略。该文主要对近年来雌激素及其受体影响胆固醇结石形成的研究进展进行综述。

关键词： 胆固醇结石; 雌激素; 雌激素受体; 胆固醇; 胆汁酸

本文引用格式

庄谦 , 董志霞 , 宛新建 . 雌激素及其受体影响胆固醇结石形成的研究进展[J]. 上海交通大学学报（医学版）, 2021 , 41(10) : 1394 -1396 . DOI: 10.3969/j.issn.1674-8115.2021.10.020

Abstract

Gallstone disease is a common disorder of the digestive system. Cholesterol supersaturation in bile and gallbladder contraction dysfunction are important pathophysiological mechanisms of cholesterol gallstone formation. Estrogen and its receptors can affect cholesterol gallstone formation through regulating cholesterol and bile acid metabolism and gallbladder contraction. Classical nuclear receptors such as estrogen receptor α and estrogen receptorβ, as well as novel membrane receptors such as G protein-coupled receptor 30, play an important role in cholesterol gallstone formation. The design and synthesis of selective antagonists targeting estrogen receptors may be a potential strategy for the prevention and treatment of cholesterol gallstone disease. In this paper, the research progress of effect of estrogen and its receptors on cholesterol gallstone disease in recent years is reviewed.

Key words： cholesterol gallstone disease; estrogen; estrogen receptor (ER); cholesterol; bile acid

参考文献

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