上海交通大学学报（医学版）

上海交通大学学报（医学版） >

2023 , Vol. 43 >Issue 4: 466 - 473

DOI: https://doi.org/10.3969/j.issn.1674-8115.2023.04.009

论著 · 循证医学

脂质蓄积指数与中国成年人高血压关系的meta分析

  • 马卓然 ,
  • 袁安彩 ,
  • 蒋惠如 ,
  • 陈潇雨 ,
  • 张薇 ,
  • 卜军
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  • 1.蚌埠医学院公共卫生学院，蚌埠 233030
    2.上海交通大学医学院附属仁济医院心内科，上海 200127
    3.上海交通大学医学院附属仁济医院临床研究中心，上海 200127
马卓然（1998—），女，硕士生；电子信箱：asd3ggb@qq.com。
卜 军，电子信箱：pujun310@hotmail.com。
张 薇，电子信箱：zhangwei050080@renji.com

收稿日期: 2022-10-25

  录用日期: 2023-03-14

  网络出版日期: 2023-04-28

基金资助

上海市专业技术服务平台建设项目(22DZ2292400);上海市卫生健康委员会新兴交叉领域研究专项(2022JC013);上海市卫生健康委员会临床重点专科建设项目(SHSLCZDZK06204)

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Meta analysis of correlation between lipid accumulation product and hypertension in Chinese adults

  • Zhuoran MA ,
  • Ancai YUAN ,
  • Huiru JIANG ,
  • Xiaoyu CHEN ,
  • Wei ZHANG ,
  • Jun PU
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  • 1.School of Public Health, Bengbu Medical College, Bengbu 233030, China
    2.Department of Cardiology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China
    3.Center for Clinical Investigation, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China
PU Jun, E-mail: pujun310@hotmail.com.
ZHANG Wei, E-mail: zhangwei050080@renji.com

Received date: 2022-10-25

  Accepted date: 2023-03-14

  Online published: 2023-04-28

Supported by

Key Research Center Construction Project of Shanghai(22DZ2292400);Emerging Interdisciplinary Research Project of Shanghai Municipal Health Commission(2022JC013);Key Clinical Specialty of Shanghai Municipal Health Commission(SHSLCZDZK06204)

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摘要

目的·探讨脂质蓄积指数（lipid accumulation product，LAP）与中国成年人高血压的关系。方法·通过检索英文数据库PubMed、Web of Science，中文数据库中国知网、万方数据知识服务平台，搜集从建库到2022年8月中国成年人LAP与高血压相关研究。由2位研究人员根据纳入和排除标准分别独立地对所有检索到的文献进行筛选，并使用JBI（Joanna Briggs Institute）诊断性研究量表对研究人群选择、可比性、暴露评价和结果等方面进行文献质量评估。对纳入的文献提取样本量、性别、灵敏度、特异度等信息，并使用Stata 16.0软件进行meta分析。结果·共纳入6篇文献，其中英文文献5篇，中文文献1篇。纳入文献的JBI偏倚评分为14~17分，均大于总分的70%，认为偏倚较小。纳入样本总数48 329例，其中高血压患者15 746例。Meta分析结果显示，在总人群中，LAP预测高血压的灵敏度为0.50（95%CI 0.35~0.64），特异度为0.78（95%CI 0.66~0.86）；在女性中灵敏度为0.48（95%CI 0.32~0.64），特异度为0.77（95%CI 0.64~0.86）；在男性中灵敏度为0.56（95%CI 0.39~0.72），特异度为0.64（95%CI 0.49~0.77）。纳入的总体人群综合受试者操作特征曲线（summary receiver operator characteristic curve，SROC曲线）下面积为0.70（95%CI 0.66~0.74），表明LAP和高血压存在一定的相关性。结论·在中国成年人群中，LAP与高血压有一定关联性。

关键词： 脂质蓄积指数; 高血压; 成年人; 中国人; meta分析

本文引用格式

马卓然 , 袁安彩 , 蒋惠如 , 陈潇雨 , 张薇 , 卜军 . 脂质蓄积指数与中国成年人高血压关系的meta分析[J]. 上海交通大学学报（医学版）, 2023 , 43(4) : 466 -473 . DOI: 10.3969/j.issn.1674-8115.2023.04.009

Abstract

Objective ·To explore the correlation between lipid accumulation product (LAP) and hypertension in Chinese adults. Methods ·By searching the English literature databases including PubMed and Web of Science, and the Chinese literature databases including CNKI and WanFang Data Knowledge Service Platform database, the earliest literature related to LAP and hypertension in Chinese adults that could be retrieved from databases establishment to August 2022. Two researchers independently screened all the retrieved literature according to the inclusion and exclusion criteria, and used the diagnostic research scale developed by Joanna Briggs Institute (JBI) to evaluate the literature quality of the selection, comparability, exposure evaluation and results of the study population. The sample size, gender, sensitivity, specificity and other information were extracted from the included literature. Stata 16.0 software was used for meta-analysis. Results ·A total of 6 articles were included, including five in English and one in Chinese. The JBI bias scores of the included articles ranged from 14 to 17 points, all of which were greater than 70% of the total score, so the biases could be considered small. The total number of samples included was 48 329, including 15 746 patients with hypertension. The results of meta-analysis showed that in the total population, the sensitivity of LAP in predicting hypertension was 0.50 (95%CI 0.35?0.64), and the specificity was 0.78 (95%CI 0.66?0.86); In women, the sensitivity was 0.48 (95%CI 0.32?0.64), and the specificity was 0.77 (95%CI 0.64?0.86); In males, the sensitivity was 0.56 (95%CI 0.39?0.72), and the specificity was 0.64 (95%CI 0.49?0.77). The area under the summary receiver operator characteristic curve (SROC curve) of the total population included was 0.70 (95%CI 0.66?0.74), indicating that there was a certain correlation between LAP and hypertension. Conclusion ·In Chinese adult population, LAP is associated with hypertension to a certain extent.

Key words： lipid accumulation product (LAP); hypertension; adult; Chinese; meta-analysis

参考文献

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